一种新型吲哚并[3,2-b]咔唑化合物合成方法  

A New Synthesis Method of Indolo[3,2-b]carbazole Compound

作　　者：余立明[1] 李瑞 李永凯 周文欣[1] 陈杰英[1] YU Liming;LI Rui;LI Yongkai;ZHOU Wenxin;CHEN Jieying(Institute of Chemistry Co. Ltd.,Henan Academy of Sciences,Zhengzhou 450002,China)

机构地区：[1]河南省科学院化学研究所有限公司,郑州450002

出　　处：《河南科学》2019年第2期194-197,共4页Henan Science

基　　金：河南省科技开放合作项目(182106000015);河南省科学院科研开发项目(18ZT03011;18ZS03009)

摘　　要：以3-氨基-N-苯基咔唑为起始原料,经溴化反应、Suzuki偶联反应和Buchwald偶联反应合成了5,11-二氢-5-苯基吲哚并[3,2-b]咔唑,通过~1H NMR对化合物结构进行了表征.研究了反应温度、催化剂用量以及反应时间等因素对产物收率的影响,得到了最佳反应条件:反应温度100℃,反应时间18 h,催化剂用量为3-氨基-N-苯基咔唑摩尔量的4%.5,11-dihydro-5-phenylindoles[3,2-b]carbazole was synthesized by the bromination reaction,Suzuki reaction and Buchwald reaction using 3-amino-N-phenylcarbazole as the raw material in this paper. The structure of compound was characterized by ^1H NMR. The effects of reaction temperature,the amount of catalyst and reaction time on the yield of target compound were studied. Results showed that the optimum conditions was under the temperature of 100 ℃,the reaction time was 18 h and the amount of catalyst was 4% by mole of 3- amino-N-phenyl carbazole.

关 键 词：咔唑 合成 吲哚并[3 2-b]咔唑 

分 类 号：O625.46[理学—有机化学]