复方倍他米松联合醋酸曲安奈德皮损内注射治疗活动期斑秃疗效分析  

Clinical Efficacy of Compound Betamethasone Injection and Triamcinolone Acetonide Injection in the Treatment of Active Alopecia Areata

作　　者：黄永[1] 冯菁 顾礼忠[1] HUANG Yong;FENG Jing;GU Li-zhong(Department of Dermatology,Tianjin Public Security Hospital,Tianjin 300042,China)

机构地区：[1]天津市公安医院皮肤科,天津300042

出　　处：《中国美容医学》2019年第3期83-86,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:研究复方倍他米松联合醋酸曲安奈德注射液皮损内注射治疗活动期斑秃的疗效。方法:选择2017年1月-2017年12月笔者科室收治的80例活动期斑秃患者为研究对象,按照随机数字表法分为观察组与对照组,每组40例。对照组采用倍他米松与醋酸曲安奈德联合外用疗法;观察组采用复方倍他米松联合醋酸曲安奈德注射液皮损内注射疗法。对比两组患者治疗前后毛发镜评估结果、血浆P物质含量以及治疗有效率。结果:两组患者治疗前毛囊密度、毛发密度与毳毛率比较无明显差异(P>0.05),治疗后两组患者的毛囊密度和毛发密度都显著升高,毳毛率显著降低,观察组与对照组组间相比三项指标均有显著性差异(P<0.05),观察组改善程度高于对照组;两组治疗前血浆P物质水平比较无明显差异(P>0.05),治疗后血浆P物质水平比治疗前显著降低,有显著性差异(P<0.05),观察组治疗后血浆P物质水平显著低于对照组(P<0.05);观察组患者的临床总有效率显著高于对照组(P<0.05)。结论:复方倍他米松联合醋酸曲安奈德注射液皮损内注射疗法较常规外涂更能改善活动期斑秃患者的临床疗效,提高毛发镜评估结果、调低血浆P物质水平并提高临床治疗总有效率。Objective To study the effect of compound betamethasone injection combined with triamcinolone acetonide injection in the treatment of active alopecia areata. Methods A total of 80 patients with active alopecia areata treated in our hospital from January 2017 to December 2017 were randomly divided into observation group and control group according to a random numbering of 40 individuals. The control group was treated with conventional therapy. The group administered compound betamethasone injection and triamcinolone acetonide acetate intralesional injection therapy, and compared the results of hair microscopic evaluation, plasma P content, and clinical treatment efficiency between the two groups before and after treatment. Results Two groups of patients before treatment and has no obvious difference (P >0.05)in the density of hair follicle and hair and the rate of vellus hair, the two groups after treatment significantly increased the density of hair follicle and hair density of patients, the rate of hair follicle, hair density and the rate of vellus hair significantly decreased(P <0.05) between observation group and the control way compared to the three indexes had significant difference (P <0.05), improved observation group was higher than the control group. The two groups before treatment plasma levels of substance P has no obvious difference (P >0.05), plasma substance P level in the two groups after treatment than before treatment significantly reduced,There was a significant difference in the data between the observation group and the control group(P <0.05), and the plasma substance P level of the observation group was significantly lower than that of the control group (P <0.05). The total clinical efficiency of the observation group was significantly higher than that of the control group (P <0.05). Conclusion Conventional betamethasone cream plus triamcinolone acetonide cream plus topical betamethasone and triamcinolone acetonide injections can improve clinical outcomes in patients with active alopecia area

关 键 词：复方倍他米松 醋酸曲安奈德 活动期斑秃 皮损内注射 毛囊密度 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]