抑制素B在多囊卵巢综合征患者卵巢刺激过程中的临床价值  

Clinical value of inhibin B in ovarian stimulation process of patients with polycystic ovary syndrome

作　　者：刘倩[1] 刘小青[1] 刘伟[1] 李冬月[1] 李力[1] LIU Qian;LIU Xiaoqing;LIU Wei;LI Dongyue;LI Li(Department of Obstetrics and Gynecology,East Hospital of Baoding MunicipalFirst Central Hospital,Baoding,Hebei 071000,China)

机构地区：[1]河北省保定市第一中心医院东院妇产科,071000

出　　处：《检验医学与临床》2019年第5期630-634,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨抑制素B(inhibin B)在多囊卵巢综合征(PCOS)患者中的表达及在卵巢刺激过程中的临床价值。方法选取2013年12月至2015年1月收治的输卵管梗阻不孕患者120例,其中90例PCOS患者作为PCOS组,30例非PCOS患者作为非PCOS组,PCOS患者采用双压降调节的卵巢刺激方案,非PCOS组采用黄体期短效长方案,检测两组患者控制性卵巢刺激(COS)不同时期[月经周期第3天、开始注射促性腺激素释放激素激动剂日(Gn启动日)、应用促性腺激素释放激素激动剂第5天(Gn第5日)、应用人绒毛膜促性腺激素(HCG)日]血清inhibin B以及卵泡液inhibin B水平,依据inhibin B增幅水平将PCOS患者分为低增幅组、中增幅组和高增幅组,按妊娠与否将两组患者再分别分为妊娠组和非妊娠组2个亚组。结果 PCOS组月经周期第3天、Gn启动日、Gn第5日、HCG日血清和卵泡液inhibin B水平均明显高于非PCOS组(P<0.01);PCOS组中患者基础血清inhibin B水平与Gn使用剂量呈负相关(r=-0.274,P=0.034)。高增幅组和中增幅组在月经周期第3天、Gn启动日、Gn第5日、HCG日inhibin B水平均显著高于低增幅组(P<0.05);高增幅组和中增幅组在Gn使用总量、COS天数显著低于低增幅组,获卵数显著高于低增幅组(P<0.05);非PCOS患者妊娠组取卵日的卵泡液inhibin B水平和基础血清inhibin B、可移植胚胎数显著高于非妊娠组(P<0.05)。结论 PCOS患者血清inhibin B水平与Gn用量呈负相关,COS过程中促排卵早期的血清inhibin B的增幅程度可指导Gn应用剂量,但inhibin B水平不能用于预测PCOS患者的妊娠结局。Objective To investigate the expression of inhibin B in the patients with polycystic ovary syndrome(PCOS)and its clinical value in ovarian stimulation process.Methods One hundred and twenty cases of oviduct obstruction infertility treated in our hospital from December2013 to January2015,including 90 cases of PCOS in the PCOS group and 30 cases in the non-PCOS group.The PCOS patients adopted the double pressure drop mediating ovarian stimulation scheme,and the non-PCOS group used the short term effect and long scheme in luteal phase.The serum inhibin B and follicular fluid inhibin B levels in different periods of COS(3 d of menstrual cycle,Gn start day,5 d of using Gn,day of HCG use)were measured.The patients were divided into the low increasing range group,medium increasing range group and high increasing range group according to the level of inhibin B increasing range,and the pregnancy group and non-pregnancy group according to whether pregnancy.Results The follicular fluid inhibin B level on 3 d of menstrual cycle,Gn start day,5 d of Gn and day of HCG use in the PCOS group were significantly higher than those in the non-PCOS group(P<0.05);in the PCOS group,the basic serum inhibin B level was negatively correlated with the Gn dosage(r=-0.274,P=0.034).The inhibin B level on 3 d of menstrual cycle,Gn start day,5 d of Gn and day of HCG use in the high increasing range group and medium increasing range growth group were significantly higher than those in low increasing range group(P<0.05).The total amount of Gn use and the number of COS days in the high increasing range group and medium increasing range group were significantly lower than those in the low increasing range group,and the number of retrieved oocytes was significantly higher than that in the low increasing range group(P<0.05).In the non PCOS group,the follicular fluid inhibin B level,basic serum inhibin B and the number of transplantable embryos were significantly higher than those in the non-pregnant group(P<0.05).Conclusion The serum inhibin B level i

关 键 词：抑制素B 多囊卵巢综合征 卵巢刺激 体外授精-胚胎移植 

分 类 号：R711.75[医药卫生—妇产科学]