红细胞免疫及血清炎性因子水平与轮状病毒肠炎患儿脱水程度的关系  

Relationship between erythrocyte immunity, level of serum inflammatory factors and degree of dehydration in children with rotavirus enteritis

作　　者：殷佟 袁博[2] 黄雅玲 高健 张岚[3] YIN Tong;YUAN Bo;HUANG Yaling;GAO Jian;ZHANG Lan(Department of Pediatrics, General Hospital of Fuxin Mining Industry (Group) Company with Limited Liability, Liaoning Province, Fuxin 123000, Chian;Department of General Surgery, Xi′an Central Hospital, Shaanxi Province, Xi′an 710003, China;Department of Neonatal, Second Affiliated Hospital of Xi′an Jiao Tong University, Shaanxi Province, Xi′an 710003, China)

机构地区：[1]阜新矿业(集团)有限责任公司总医院儿科,辽宁阜新123000 [2]西安市中心医院普外科,陕西西安710003 [3]西安交通大学第二附属医院新生儿科,陕西西安710003

出　　处：《中国医药导报》2019年第6期86-89,共4页China Medical Herald

基　　金：辽宁省自然科学基金项目(2015020490)

摘　　要：目的研究红细胞免疫及血清炎性因子水平与轮状病毒肠炎患儿脱水程度的关系。方法回顾性分析2015年2月～2018年2月阜新矿业(集团)有限责任公司总医院收治的82例轮状病毒肠炎患儿的临床资料,将其按照脱水程度不同分为轻度脱水组(25例)、中度脱水组(27例)、重度脱水组(30例)。另取同期进行体检的健康儿童30名为对照组。分别对比各组各项红细胞免疫指标与血清炎性因子水平,并作相关性分析。结果对照组、轻度脱水组、中度脱水组、重度脱水组免疫黏附促进因子(RFER)、红细胞促中性粒细胞吞噬率(ERPN)、红细胞C3b受体花环率(RBC-C3bR)水平均逐渐降低,而免疫黏附抑制因子(FEIR)与免疫复合物花环率(RBC-ICR)水平逐渐上升,差异均有统计学意义(P <0.05)。对照组、轻度脱水组、中度脱水组、重度脱水组肿瘤坏死因子α(TNF-α)、降钙素原(PCT)以及超敏C反应蛋白(hs-CRP)水平均逐渐升高,差异均有统计学意义(P <0.05)。经Spearman相关性分析可得:TNF-α、PCT、hs-CRP与RFER、ERPN、RBC-C3bR均呈负相关(P <0.05),而与FEIR、RBC-ICR均呈正相关(P <0.05)。结论红细胞免疫及血清炎性因子水平与轮状病毒肠炎患儿的脱水程度密切相关,可为轮状病毒肠炎患儿疾病诊断和严重程度评估提供依据。Objective To study the relationship between erythrocyte immunity, level of serum inflammatory factors and the degree of dehydration in children with rotavirus enteritis. Methods From February 2015 to February 2018, in General Hospital of Fuxin Mining Industry (Group) Company with Limited Liability, the clinical data of 82 children with rotavirus enteritis were retrospectively analyzed, according to the degree of dehydration, they were divided into mild dehydration group (25 cases), moderate dehydration group (27 cases), and severe dehydration group (30 cases), another 30 healthy children had physical examination were selected as control group. The level of erythrocyte immune indexes and serum inflammatory factors in each group was compared, and correlation analysis was made. Results The level of immune adherence enhance factor (RFER), enhancing rosette rate of phygocytosis of red cells on neutrophils (ERPN) and erythrocyte C3b receptor rosette rate (RBC-C3bR) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group decreased gradually, the level of immune adherence inhibitor factor (RFIR) and immunocomplex receptor chaplet rate (RBC-ICR) increased gradually, the differences were statistically significant (P < 0.05). The level of tumor necrosis factor-α(TNF-α), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group increased gradually, the differences were statistically significant (P < 0.05). Spearman correlation analysis showed that TNF-α, PCT, hs-CRP were negatively correlated with RFER, ERPN, RBC-C3bR (P < 0.05),they were positively correlated with FEIR and RBC-ICR (P < 0.05). Conclusion The level of erythrocyte immunity and serum inflammatory factors are closely related to the degree of dehydration in children with rotavirus enteritis, it can provide basis for disease diagnosis and severity assessment of children with rotavirus enteritis.

关 键 词：轮状病毒肠炎 红细胞免疫 炎性因子 患儿 脱水程度 

分 类 号：R725.6[医药卫生—儿科]