Lattice Boltzmann model of percutaneous drug absorption  

作　　者：Arman Safdari Kyung Chun Kim 

机构地区：[1]School of Mechanical Engineering, Pusan National University

出　　处：《Theoretical & Applied Mechanics Letters》2019年第1期1-6,I0006,共7页力学快报（英文版）

基　　金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(2011-0030013 and 2018R1A2B2007117)

摘　　要：A lattice Boltzmann numerical modeling method was developed to predict skin concentration after topical application of a drug on the skin. The method is based on D2Q9 lattice spaces associated with the Bhatnagar-Gross-Krook(BGK) collision term to solve the convection-diffusion equation(CDE). A simulation was carried out in different ranges of the value of bound γ, which is related to skin capillary clearance and the volume of diffusion during a percutaneous absorption process. When a typical drug is used on the skin, the value of γ corresponds to the amount of drug absorbed by the blood and the absorption of the drug added to the skin. The effect of γ was studied for when the region of skin contact is a line segment on the skin surface.A lattice Boltzmann numerical modeling method was developed to predict skin concentration after topical application of a drug on the skin. The method is based on D2Q9 lattice spaces associated with the Bhatnagar-Gross-Krook(BGK) collision term to solve the convection-diffusion equation(CDE). A simulation was carried out in different ranges of the value of bound γ, which is related to skin capillary clearance and the volume of diffusion during a percutaneous absorption process. When a typical drug is used on the skin, the value of γ corresponds to the amount of drug absorbed by the blood and the absorption of the drug added to the skin. The effect of γ was studied for when the region of skin contact is a line segment on the skin surface.

关 键 词：Lattice BOLTZMANN method Bhatnagar-Gross-Krook (BGK) Single relaxation time ADVECTION-DIFFUSION CONVECTION-DIFFUSION equation (CDE) 

分 类 号：O3[理学—力学]