阿托伐他汀辅助治疗慢性肾炎的效果、安全性及相关指标的影响  

Curative effect,safety and the effect on related indexes of atorvastatin in adjuvant treatment of chronic nephritis

作　　者：刘伟莉[1] 潘福林 黄耿[1] 李萍华[1] 张斯汉[1] 陈再强[1] 陈薇薇[1] 邵雷[1] 何成文[1] LIU Weili;PAN Fulin;HUANG Geng;LI Pinghua;ZHANG Sihan;CHEN Zaiqiang;CHEN Weiwei;SHAO Lei;HE Chengwen(Department of Nephrology,Shenzhen Longgang District People’s Hospital,Shenzhen 518172,China)

机构地区：[1]深圳市龙岗区人民医院肾内科,广东深圳518172

出　　处：《中国医药科学》2019年第2期56-58,共3页China Medicine And Pharmacy

摘　　要：目的研究阿托伐他汀辅助治疗慢性肾炎患者临床疗效、安全性及相关指标的影响。方法以2015年7月～2016年7月在本院治疗的60例慢性肾炎患者作为研究对象,随机分为对照组(30例)与观察组(30例)。在常规治疗基础上,对照组予以缬沙坦治疗,观察组予以阿托伐他汀+缬沙坦治疗。两组均治疗180d后,对比分析两组临床治疗效果,检测治疗前后两组血清肌酐(Scr)、24h尿蛋白定量(24h pro)、尿素氮(BUN)、肾小球滤过率(GFR)、C反应蛋白(CRP)的变化,并随访270d后的不良反应发生情况。结果观察组患者总有效率明显优于对照组,Scr、24h pro、BUN及CRP相比于对照组降低,且GFR升高,差异均有统计学意义(P <0.05)。两组不良反应发生率对比,观察组为3.33%,对照组为0,差异无统计学意义(P> 0.05)。结论在常规治疗基础上,阿托伐他汀辅助治疗慢性肾炎效果显著,可有效改善肾功能,促进患者康复,且安全性较高,值得临床推荐。Objective To study the clinical curative effect,safety and the effect on related indexes of atorvastatin in adjuvant treatment of chronic nephritis.Methods Sixty patients with chronic nephritis who were treated in our hospital from July 2015 to July 2016 were selected as research samples.They were randomly divided into the control group(30 cases)and the observation group(30 cases).On basis of routine treatment,the control group was treated by valsartan while the observation group was treated with atorvastatin and valsartan.After 180 days of treatment in two groups,clinical curative effects of two groups were compared and analyzed.Before and after treatment,changes of serum creatinine(Scr),24 hours urinary protein(24h pro),blood urea nitrogen(BUN),glomerular filtration rate(GFR)and C-reactive protein(CRP)in two groups were detected.The incidence of adverse reactions after 270 days was followed up.Results The total effective rate of the observation group was significantly better than that of the control group.The 24h pro,Scr,BUN and CRP of the observation group were lower than those in the control group,and GFR was higher than the control group.The difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.33%,and that in the control group was 0.00%.The difference had no statistical significance(P>0.05).Conclusion On the basis of conventional treatment,atorvastatin in adjuvant treatment of chronic nephritis has significant curative effects.It can effectively improve renal function and promote the recovery of patients and it is safe,which is worthy of clinical recommendation.

关 键 词：阿托伐他汀 缬沙坦 慢性肾炎 临床疗效 安全性 

分 类 号：R692.3[医药卫生—泌尿科学]