性激素比值预测特发性少精子症愈后的意义  

Prognostic value of sex hormone ratio on treatment of idiopathic oligospermia

作　　者：袁启龙 陈志强 陆杉 卢兴宏 倪运萍 蒋满波 周文 Qi-long Yuan;Zhi-qiang Chen;Shan Lu;Xing-hong Lu;Yun-ping Ni;Man-bo Jiang;Wen Zhou(Department of Reproductive Medicine,Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China)

机构地区：[1]广州中医药大学第二附属医院生殖医学科,广东广州510006

出　　处：《中国现代医学杂志》2019年第5期70-73,共4页China Journal of Modern Medicine

基　　金：广东省医学科研基金项目(No:A2017152)

摘　　要：目的通过分析不同疗效组间促卵泡生成素(FSH)与促黄体生成素(LH)的比值和睾酮(T)与LH的比值有无区别,探讨性激素内部比值对他莫昔芬治疗特发性少精子症疗效有无临床预测意义。方法筛选出性激素单项指标均在正常范围,经过他莫昔芬治疗呈现不同疗效的特发性少精子症患者131例,分为3组:治愈组49例、改善组36例、无效组46例。回顾性分析各组治疗前性激素内部比值水平(FSH/LH和T/LH)及单项指标有无区别。结果治愈组、有效组、无效组3组的FSH/LH比值分别为(1.163±0.409)、(1.478±0.524)、(1.930±0.558),3组比较差异有统计学意义(P <0.05),任意两组间经LSD-t检验差异有统计学意义(P <0.05);治愈组、有效组、无效组3组的T/LH比值分别为(3.931±1.432)、(3.438±1.583)、(3.165±1.522),3组比较差异有统计学意义(P <0.05),其中治愈组和无效组间比较差异有统计学意义(P <0.05);单项指标FSH 3组比较差异有统计学意义(P <0.05),但3组间LH和T指标比较差异无统计学意义(P>0.05),仅LH值治愈组和无效组比较差异有统计学意义(P <0.05)。结论与性激素单项检测指标比较,内部比值(FSH/LH和T/LH)对他莫昔芬治疗特发性少精子症的愈后判断更有临床意义。Objective To investigate the effect of sex hormone internal ratio(FSH/LH and T/LH)in patients with idiopathic oligospermia post treatment of Tamoxifen.Methods A total of 131 idiopathic spermatozoa patients were involved and divided into three groups according to curative effects:full cure group(n=49),partial cure group(n=36)and no-response group(n=46).Results The FSH/LH ratio in full cure group,effective group,and no-response group was(1.163±0.409),(1.478±0.524),and(1.930±0.558),respectively.Statistically significant difference in FSH/LH ratio was identified in two groups.The T/LH ratio in full cure group,effective group,and noresponse group was(3.931±1.432,(3.438±1.583),and(3.165±1.522),respectively.Significant difference in T/LH was identified between full cure group and no-response group.Concentrations of FSH were statistically significant different among three groups while only concentration of LH was obviously different between full cure group and no-response group.Conclusions The internal rates of sex hormones(FSH/LH and T/LH)may be used as predictive markers in predicting the efficacy of Tamoxifen citrate in treatment of idiopathic oligospermia.

关 键 词：少精子症 雄激素类 比值 他莫昔芬 

分 类 号：R698.2[医药卫生—泌尿科学]