达克罗宁对全身麻醉诱导气管插管期间应激反应及术后咽喉疼痛的影响  

Effect of Dyclonine on Stress Response During Tracheal Intubation of General Anesthesia Induction and Postoperative Sore Throat

作　　者：夏勇 宋健 吴浩 XIA Yong;SONG Jian;WU Hao(Ezhou Maternal and Child Health Hospital,Ezhou,Hubei,China 436000;Ezhoo Central Hospital,Ezhoo,Hubei,China 436000)

机构地区：[1]湖北省鄂州市妇幼保健院,湖北鄂州436000 [2]湖北省鄂州市中心医院,湖北鄂州436000

出　　处：《中国药业》2019年第6期42-44,共3页China Pharmaceuticals

基　　金：湖北省自然科学基金[2016CKB701]

摘　　要：目的探讨达克罗宁胶浆对全身麻醉(简称全麻)诱导气管插管期间应激反应及术后咽喉疼痛的影响。方法选择鄂州市妇幼保健院2016年10月至2017年10月行全麻诱导气管插管手术的患者196例,按随机数字表法分为观察组和对照组,各98例。两组患者均采用相同方法诱导和维持麻醉,气管插管前,观察组患者使用盐酸达克罗宁胶浆,对照组患者使用石蜡油涂抹气管导管和套囊。结果与麻醉诱导前(T_0)比较,两组患者在插管即刻(T_1)、插管后3 min(T_2)、插管后5 min(T_3)、插管后10 min(T_4)时心率均显著加快,且在T_1时,观察组显著慢于对照组(P <0. 05),两组患者T_1时平均动脉压显著升高,且观察组显著低于对照组(P <0. 05);观察组患者咽喉黏膜反应、咽喉疼痛、声嘶症状评分及苏醒期躁动评分均显著低于对照组(P <0. 05)。结论达克罗宁胶浆可减轻全麻手术患者气管插管期间的应激反应,减少插管和拔管对咽喉的刺激,减轻咽喉疼痛,进而减少苏醒期躁动。Objective To investigate the effect of Dyclonine Hydrochloride Mucilage on the stress response during tracheal intubation of general anesthesia induction and postoperative sore throat.Methods Totally 196 patients undergoing tracheal intubation of general anesthesia induction admitted to Ezhou Maternal and Child Health Hospital from October 2016 to October 2017 were divided into the obserca-tion group and the control group according to the random number table method,98 cases in each group.The patients in the two groups were given the same method for the induction and maintenance of anesthesia,before tracheal intubation,the patients in the observation group were given Dyclonine Hydrochloride Mucilage,while the tracheal tubes and cuffs for patients in the control group were smeared with paraffin oil.Results Compared with the before induction(T0),the heart rates of the two groups were significantly increased at the time of intubation(T1),3 min after intubation(T2),5 min after intubation(T3)and 10 min after intubation(T3),and the heart rate of the observation group was significantly slower than that of the control group at T1(P<0.05).At T1,the levels of mean arterial pressure(MAP)in the two groups were significantly higher than those at T0,and the level of MAP in the observation group was lower than that in the control group(P<0.05).The scores of laryngopharyngeal mucosal reaction,sore throat,hoarseness symptom and pediatric anesthesia emergence delirium(PDCA)score in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Dyclonine Hydrochloride Mucilage can relieve the stress response of patients during tracheal intubation of general anesthesia,reduce the irritation of intubation and extubation towards the throat,and relieve sore throat,thereby reducing emergence agitation.

关 键 词：达克罗宁胶浆 全身麻醉 气管插管 应激反应 咽喉疼痛 苏醒期躁动 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]