血凝酶联合泮托拉唑治疗急性上消化道出血临床研究  

Clinical Study on Hemocoagulase Combined with Pantoprazole in the Treatment of Acute Upper Gastrointestinal Hemorrhage

作　　者：钟俊锋 ZHONG Junfeng(The Second Hospital of Xinyu, Xinyu, Jiangxi,China 33800)

机构地区：[1]江西省新余第二医院,江西新余338000

出　　处：《中国药业》2019年第6期55-57,共3页China Pharmaceuticals

基　　金：江西省新余市科技计划项目[20163090216]

摘　　要：目的探讨血凝酶联合泮托拉唑治疗急性上消化道出血的临床疗效。方法选取医院2016年2月至2017年8月收治的急性上消化道出血患者98例,按治疗方法的不同分为研究组和对照组,各49例。对照组患者予以注射用泮托拉唑钠,研究组患者在此基础上加用注射用矛头蝮蛇血凝酶。结果研究组总有效率为93. 88%,明显高于对照组的75. 51%(χ~2=16. 282,P <0. 01);与治疗前比较,两组患者治疗后的肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)水平明显降低(P <0. 05),且研究组明显低于对照组(P <0. 01);与对照组比较,研究组患者止血时间明显缩短,再出血率、并发症发生率均明显降低(P <0. 05)。结论血凝酶联合泮托拉唑可用于急性上消化道出血的治疗,其机制与降低炎性因子水平有关,可缩短止血时间,降低再出血率和并发症发生率。Objective To investigate the clinical effect of hemocoagulase combined with pantoprazole in the treatment of acute upper gastrointestinal hemorrhage.Methods Totally 98 patients with acute upper gastrointestinal hemorrhage admitted to our hospital from February 2016 to August 2017 were selected and divided into the study group and the control group according to the different treatment methods,49 cases in each group.The patients in the control group were treated with Pantoprazole Sodium for Injection,on this basis,the patients in the study group were treated with Hemocoagulase Bothrcps Atrox for Injection.Results The total effective rate of the study group was 93.88%,which was significantly higher than 75.51%of the control group(X^2=16.282,P<0.01).Compared with before treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups were significantly lower after treatment(P<0.05),and those in the study group were significantly lower than those in the control group(P<0.01).Compared with the control group,the hemostasis time was significantly shortened,the rate of re-bleeding and the incidence rate of complications were significantly lower in the study group(P<0.05).Conclusion Hemocoagulase combined with pantoprazole can be used in the treatment of acute upper gastrointestinal hemorrhage.Its mechanism is related to reducing the level of inflammatory factors,shortening the hemostasis time,reducing the rate of re-bleeding and the incidence rate of complications.

关 键 词：急性上消化道出血 血凝酶 泮托拉唑 临床疗效 炎性反应 

分 类 号：R969.4[医药卫生—药理学] R975[医药卫生—药学]