血清心肌肌钙蛋白T、氨基末端B型利钠肽前体、尿酸水平与慢性心力衰竭患者心功能的相关性研究  

Relationship between Serum Level of cTnT,of NT-proBNP,of UA and Cardiac Function in Patients with Chronic Heart Failure

作　　者：胡荣权 苏伟青[1] 吴阿兰 杨锐能 HU Rongquan;SU Weiqing;WU Alan;YANG Ruineng(The Second Division,Department of Cardiovascular Medicine,the People's Hospital of Lianjiang,Lianjiang 524400, China)

机构地区：[1]广东省廉江市人民医院心血管内科二区,524400

出　　处：《实用心脑肺血管病杂志》2019年第1期40-43,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：湛江市科技计划项目(2017B01080)

摘　　要：背景研究表明,心肌肌钙蛋白T(cTnT)、氨基末端B型利钠肽前体(NT-proBNP)、尿酸(UA均参与慢性心力衰竭的发生发展,但目前三者与慢性心力衰竭患者心功能的相关性研究报道较少。目的分析血清cTnT、NT-proBNP、UA水平与慢性心力衰竭患者心功能的相关性。方法选取2015年1月—2018年1月廉江市人民医院心血管内科收治的慢性心力衰竭患者48例,其中纽约心脏病协会(NYHA)分级Ⅱ级16例,Ⅲ级16例,Ⅳ级16例。比较不同NYHA分级患者一般资料及血清cTnT、NT-proBNP、UA水平,血清cTnT、NT-proBNP、UA水平与慢性心力衰竭患者NYHA分级的相关性分析采用多元线性回归分析。结果不同NYHA分级患者性别、年龄、原发病比较,差异无统计学意义(P>0.05);NYHA分级Ⅳ级患者血清cTnT、NT-proBNP、UA水平高于NYHA分级Ⅱ、Ⅲ级患者,NYHA分级Ⅲ级患者血清cTnT、NT-proBNP、UA水平高于NYHA分级Ⅱ级患者(P<0.05)。多元线性回归分析结果显示,血清cTnT(β=0.001)、NT-proBNP(β=0.000)、UA(β=0.012)水平与慢性心力衰竭患者NYHA分级呈正相关(P<0.05)。结论慢性心力衰竭患者血清cTnT、NT-proBNP、UA水平随着NYHA分级增大而升高,三者均与慢性心力衰竭患者心功能呈正相关。Background Researches show that,cTnT,NT-proBNP and UA play important roles in the occurrence and development of chronic heart failure,but there is relatively few research reports about correlations of above three with cardiac function of patients with chronic heart failure. Objective To analyze the relationship between serum level of cTnT, of NT-proBNP,of UA and cardiac function in patients with chronic heart failure. Methods From January 2015 to January 2018,48 patients with chronic heart failure were selected in the Department of Cardiovascular Medicine,the People's Hospital of Lianjiang,including 16 cases with Ⅱ-grade NYHA classification,16 cases with Ⅲ-grade NYHA classification,16 cases with Ⅳ-grade NYHA classification. General information,serum levels of cTnT,NT-proBNP and UA were compared in patients with different NYHA classification,and multivariate linear-regression analysis was used to analyze the correlations of serum levels of cTnT,NT-proBNP and UA with NYHA classification in patients with chronic heart failure. Results No statistically significant difference of gender,age or primary illness was found in patients with different NYHA classification(P>0.05);serum levels of cTnT,NT-proBNP and UA in patients with Ⅳ-grade NYHA classification were statistically significantly higher than those in patients with Ⅱ-,Ⅲ-grade NYHA classification,serum levels of cTnT,NT-proBNP and UA in patients with Ⅲ-grade NYHA classification were statistically significantly higher than those in patients with Ⅱ-grade NYHA classification (P<0.05). Multivariate linear-regression analysis results showed that,serum levels of cTnT(β=0.001),NT-proBNP (β=0.000)and UA(β=0.012)were positively correlated with NYHA classification in patients with chronic heart failure (P<0.05). Conclusion Serum levels of cTnT,NT-proBNP and UA elevate as the NYHA classification increase in patients with chronic heart failure,and above three are positively correlated with the cardiac function.

关 键 词：心力衰竭 肌钙蛋白T 氨基末端B 型利钠肽前体 尿酸 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]