去乙酰化转移酶SIRT7的作用及机制研究进展  

Progress in roles and mechanisms of deacetylase SIRT7

作　　者：李林[1,2,3] 董振[1,2,3] 杨洁[1,2,3] 李倩[4] 雷倩[1,2,3] 毛景欣[1,2,3] 杨丽群[1,2,3] 崔红娟[1,2,3] Lin Li;Zhen Dong;Jie Yang;Qian Li;Qian Lei;Jingxin Mao;Liqun Yang;Hongjuan Cui(State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China;Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400716, China;Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China;Department of Dermatology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China)

机构地区：[1]西南大学家蚕基因组生物学国家重点实验室,重庆400716 [2]西南大学重庆市蚕丝生物材料与再生医学工程技术研究中心,重庆400716 [3]西南大学肿瘤生物医学与转化工程研究中心,重庆400716 [4]河北医科大学第三附属医院皮肤科,河北石家庄050051

出　　处：《生物工程学报》2019年第1期13-26,共14页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.31672496);重庆高校创新团队建设计划(No.CXTDX201601010);重庆市基础与前沿研究计划项目(No.cstc2016jcyjA0425)资助~~

摘　　要：SIRT7是哺乳动物Sirtuins家族中的一员,定位于核仁,是一种高度特异性的H3K18Ac(组蛋白H3的乙酰化18位赖氨酸残基)去乙酰化酶。近年来的研究发现SIRT7可通过多种途径参与调控核糖体RNA转录、细胞代谢、细胞应激以及DNA损伤修复等生理过程。此外,SIRT7还与衰老、心脏疾病及脂肪肝等密切相关。特别是SIRT7在多种肿瘤如肝癌、胃癌、乳腺癌、膀胱癌、结直肠癌、胰腺癌和头颈鳞状细胞癌等发生发展中起着重要的调节作用。文中综述了SIRT7的细胞及分子生物学作用,并系统总结了其在人类疾病中的研究现状。As a member of the Sirtuins family in mammals,SIRT7 locates in nucleus and is a highly specific H3K18Ac(acetylated lysine 18 of histone H3) deacetylase.Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription,cell metabolism,cell stress and DNA damage repair through various signaling pathways.In addition,SIRT7 isalso closely related with aging,heart disease and fatty liver.In particular,SIRT7 plays important roles in the regulation of initiation and development of various tumors,such as liver cancer,gastric cancer,breast cancer,bladder cancer,colorectal cancer,and head/neck squamous cell carcinoma.This review describes the cellular and molecular functions of SIRT7,and systematically summarizes recent progress of SIRT7 in human disease.

关 键 词：SIRT7 去乙酰化 肿瘤 细胞代谢 核糖体 应激反应 

分 类 号：Q55[生物学—生物化学]