晚期直肠癌应用3D腹腔镜手术联合奥沙利铂化疗的效果分析  

Effect Analysis of 3D Laparoscopic Surgery Combined with Oxaliplatin in Treatment of Advanced Rectal Cancer

作　　者：王啸飞[1] 路夷平[1] 张洪海[1] 贺志坚[1] 高建新[1] WANG Xiaofei;LU Yiping;ZHANG Honghai;HE Zhijian;GAO Jianxin(Department of Tumor Surgery,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing,100010,China)

机构地区：[1]首都医科大学附属北京中医医院肿瘤外科,北京100010

出　　处：《肿瘤药学》2018年第6期867-870,共4页Anti-Tumor Pharmacy

基　　金：国家自然科学基金资助项目(30672042)

摘　　要：目的探究晚期直肠癌应用3D腹腔镜手术联合奥沙利铂化疗的效果及对患者生存时间的影响。方法选取我院收治的140例晚期直肠癌患者,按随机数字表法分为对照组(70例)和观察组(70例),对照组患者采用常规开腹手术联合奥沙利铂化疗,观察组患者采用3D腹腔镜手术联合奥沙利铂化疗。比较两组患者的治疗有效率、手术效果、复发率、并发症发生率以及生活质量。结果观察组患者治疗有效率显著高于对照组(P<0.05);观察组患者复发率明显低于对照组(P<0.05);观察组患者并发症发生率明显低于对照组(P<0.05);观察组患者住院时间、手术时间、下床活动时间、排便时间、术中出血量以及进食时间明显低于对照组(P<0.05)。结论应用3D腹腔镜手术联合奥沙利铂化疗治疗晚期直肠癌的临床效果显著,可降低并发症对患者的伤害,显著减轻患者痛苦,值得临床推广应用。Objective To explore the application effect of 3D laparoscopic surgery combined with oxaliplatin based chemotherapy and its effect on survival time of advanced rectal cancer patients. Methods One hundred and forty cases of advanced colorectal cancer patients enrolled in our hospital were randomly divided into control group (n=70) and observation group (n=70). The control group was treated with conventional open surgery combined with oxaliplatin,and those in observation group received 3D laparoscopic surgery combined with oxaliplatin. Observe and compare the results of operation,efficiency,recurrence rate,complications and quality of life between the two groups. Results The effective rate in the observation group was significantly higher than in control group (P<0.05). The recurrence rate of observation group was significantly lower than that of the control group (P<0.05). The complication rate was significantly lower in observation group than in control group (P<0.05). Patients of the observation group also had less amount of bleeding in operation,shorter operation time and hospitalization time,earlier out-of-bed activity,earlier defecation and earlier feeding than those of the control group (P<0.05). Conclusion The application of 3D laparoscopic surgery combined with oxaliplatin chemotherapy has a better clinical effect in the treatment of advanced rectal cancer. It can reduce the complications to patients and relieve the pain of patients,so it is worthy of clinical promotion and application.

关 键 词：晚期直肠癌 3D腹腔镜手术 奥沙利铂 生存时间 效果分析 复发率 

分 类 号：R735.37[医药卫生—肿瘤]