百令胶囊辅助治疗对稳定期COPD患者气道功能及血清气道重塑分子的影响  

Effect of Corbrin capsule on airway function and serum airway remodeling molecules in patients with stable COPD

作　　者：王新[1] 王静[2] Xin Wang;Jing Wang(Department of Respiratory and Critical Care Medicine, People’s Hospital of Deyang City, Deyang,Sichuan 618000, China;Department of Pharmacy, People’s Hospital of Deyang City,Deyang, Sichuan 618000, China)

机构地区：[1]德阳市人民医院呼吸与危重症医学科,四川德阳618000 [2]德阳市人民医院药剂科,四川德阳618000

出　　处：《中国现代医学杂志》2019年第6期88-91,共4页China Journal of Modern Medicine

摘　　要：目的探讨百令胶囊辅助治疗对稳定期慢性阻塞性肺疾病(COPD)患者气道功能及血清气道重塑分子的影响。方法选取2016年1月—2017年12月于德阳市人民医院接受治疗的稳定期COPD患者80例作为研究对象,按照随机数表法将其分为对照组和百令胶囊组。对照组患者接受临床稳定期COPD常规治疗,百令胶囊组患者在常规治疗基础上加入百令胶囊辅助治疗,持续8周。对比治疗前、治疗8周后两组患者气道功能参数水平及血清气道重塑分子含量的差异。结果百令胶囊组治疗8周后第1秒用力呼气容积、第1秒用力呼气容积占用力肺活量的比值、剩50%肺活量时的最大呼气流速、中段呼气流速及剩25%肺活量时的用力呼气流速高于对照组(P<0.05)。百令胶囊组治疗8周后转化生长因子-β_1、烟酰胺腺嘌呤二核苷酸磷酸氧化酶4、核因子-κB及基质金属蛋白酶-9低于对照组(P <0.05)。结论稳定期COPD患者在常规治疗基础上加入百令胶囊辅助治疗,可有效优化气道功能并抑制气道重塑分子的表达。Objective To study the effect of Corbrin capsule on airway function and serum airway remodeling molecules in patients with stable COPD. Methods During January 2016 to December 2017, 80 cases of stable COPD patients undergoing treatment in our hospital were selected as research subjects, and were divided into control group (n = 40) and Corbrin capsule group (n = 40). Patients in control group were treated with routine COPD treatment for 8 weeks, and those in Corbrin capsule group were treated with Corbrin capsule for 8 weeks on the basis of routine treatment. The difference of airway function parameters and serum contents of airway remodeling molecule between two groups before and 8 weeks after treatment were compared. Results Levels of airway function parameters such as FEV1, FEV1/FVC, MEF50, MEF25-75 and MEF25 in Corbrin capsule group were higher than those in control group (P < 0.05);serum contents of TGF-β1, NOX4, NF-κB and MMP-9 in Corbrin capsule group were lower than those in control group (P < 0.05). Conclusions Adding Corbrin capsules to stable COPD patients on the basis of routine treatment can effectively optimize airway function and inhibit the expression of airway remodeling molecule.

关 键 词：肺疾病 慢性阻塞性 百令胶囊/中草药 气道重塑 

分 类 号：R563.19[医药卫生—呼吸系统]