胺碘酮联合艾司洛尔静脉注射治疗室性心动过速的临床疗效研究  

Clinical effect of combined amiodarone and esmolol intravenous injection on ventricular tachycardia

作　　者：龚爽[1] 李树岩[1] Gong Shuang;Li Shuyan(Center for Cardiovascular Diseases,Jilin University No.1 Hospital,Changchun 130021,Jilin Province,China)

机构地区：[1]吉林大学第一医院心血管中心,长春130021

出　　处：《中华老年心脑血管病杂志》2019年第1期29-31,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨胺碘酮联合艾司洛尔静脉注射治疗室性心动过速的临床疗效。方法选择2016年10月～2017年10月我院心血管内科收治的室性心动过速患者77例,按照住院号单双号法分为对照组39例和观察组38例。对照组给予胺碘酮治疗,观察组给予胺碘酮联合艾司洛尔治疗。比较2组患者治疗前后的心率、收缩压、舒张压等指标变化情况,评估2组临床疗效,并观察2组不良反应发生情况。结果与治疗前比较,2组治疗后心率、收缩压及舒张压明显降低,差异有统计学意义(P <0. 05)。且观察组治疗后心率[(71±14)次/min vs (101±16)次/min]、收缩压[(110±17) mm Hg(1 mm Hg=0. 133 k Pa) vs (139±12) mm Hg]及舒张压[(72±12) mm Hg vs (88±11) mm Hg]明显低于对照组,差异有统计学意义(P <0. 05)。观察组治疗后总有效率明显高于对照组,差异有统计学意义(97. 37%vs 76. 92%,P <0. 05)。对照组与观察组不良反应发生率比较,差异无统计学意义(P> 0. 05)。结论室性心动过速采用胺碘酮联合艾司洛尔静脉注射治疗,疗效显著,能够显著改善患者心率、收缩压、舒张压指标,且不良反应少,安全性高。Objective To study the clinical effect of combined amiodarone and esmolol intravenous injection on ventricular tachycardia.Methods Seventy-seven ventricular tachycardia patients admitted to our hospital were divided into control group(n=39)and observation group(n=38).The patients in control group received amiodarone treatment and those in observation group underwent combined amiodarone and esmolol intravenous injection treatment.Their HR,SBP and DBP were compared before and after treatment.The clinical effect of combined amiodarone and esmolol intravenous injection was assessed and the adverse reactions were recorded in two groups.Results The HR,SBP and DBP were significantly lower in two groups after treatment than before treatment(P<0.05)and significantly lower in observation group than in control group after treatment(71±14/min vs 101±16/min,110±17 mm Hg vs 139±12 mm Hg,72±12 mm Hg vs 88±11 mm Hg,P<0.05).The total effective rate of combined amiodarone and esmolol intravenous injection was significantly higher in observation group than in control group(97.37%vs 76.92%,P<0.05).No significant difference was found in the incidence of adverse reactions between the two groups(P >0.05).Conclusion The therapeutic effect of combined amiodarone and esmolol intravenous injection on ventricular tachycardia is good.Combined amiodarone and esmolol intravenous injection can significantly improve the HR,SBP and DBP with few adverse reactions and a high safety.

关 键 词：胺碘酮 心动过速 室性 血流动力学 心率 

分 类 号：R541.71[医药卫生—心血管疾病]