基于网络药理学预测黄芪抗肝癌的有效成分及其潜在靶点  

Effective Components and Potential Targets of Astragalus in Treatment of Liver Cancer Based on Network Pharmacology

作　　者：王丹 王建[1] 高思佳 徐卓 王莹莹 王涛[1,2] 魏士长 赵艳玲 WANG Dan;WANG Jian;GAO Sijia;XU Zhuo;WANG Yingying;WANG Tao;WEI Shizhang;ZHAO Yanling(College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Sichuan Chengdu 611137,China;Dept.of Pharmacy,Fifth Medical Center of PLA General Hospital,Beijing 100039,China)

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]解放军总医院第五医学中心药学部,北京100039

出　　处：《中国医院用药评价与分析》2019年第1期6-8,13,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金资助项目(No.81373984)

摘　　要：目的:基于网络药理学,初步探讨预测黄芪抗肝癌的有效成分及潜在作用靶点。方法:通过建立黄芪药物靶点数据集、肝癌疾病靶点数据集,构建黄芪抗肝癌的"成分-靶点-疾病"交互网络图,并通过可视化分析,预测黄芪抗肝癌的有效成分及潜在作用靶点。结果:黄芪可能是通过直接作用于白细胞介素6、细胞肿瘤抗原p53、肝药酶CYP3A4、丝裂原活化蛋白激酶14、细胞周期素A2及肝药酶CYP2A6等蛋白靶点,并通过调节核苷酸结合寡聚化结构域样受体信号通路、肿瘤坏死因子信号通路及鞘脂信号通路等多条通路达到其治疗目的。结论:本研究通过网络药理学初步揭示了黄芪抗肝癌的潜在调控网络,为其后续实验研究及临床应用提供了参考。OBJECTIVE:To probe into the effective components and potential targets of Astragalus in anti-liver cancer based on network pharmacology.METHODS:By establishing a dataset of the drug target of Astragalus and liver cancer disease target dataset,the"ingredients-target-disease"interactive network of Astragalus in treatment of liver cancer was constructed.The active ingredients and potential effects of Astragalus to anti-liver cancer were predicted by visual analysis.RESULTS:Astragalus may act on protein targets such as interleukin-6,cell tumor antigen p53,CYP3A4,mitogen-activated protein kinase 14,cyclin A2,and CYP2A6 directly and simultaneously regulating nucleotide-binding oligomerization domain-like receptor signaling pathways,TNF signaling pathways,sphingolipid signaling pathways and other pathways to achieve their therapeutic goals.CONCLUSIONS:This study preliminarily revealed the potential regulatory network of Astragalus against liver cance through network pharmacology,which provided a reference for the follow-up experimental research and clinical application of Astragalus.

关 键 词：黄芪 肝癌 网络药理学 作用靶点 

分 类 号：R932[医药卫生—生药学] R96[医药卫生—药学]