一测多评法测定疏风清热胶囊中五种蒽醌类成分的含量  

Content Determination of Five Anthraquinones in Shufengqingre Capsules by Quantitative Analysis Multi-Components By Single Markers

作　　者：苏瑞 于如海 SU Rui;YU Ruhai(School of Traditional Chinese Medicine,Shanxi Univeisity of Traditional Chinese Medicine,Shanxi Jinzhong 030619,China;Datong Institute for Food and Drug Control,Shanxi Datong 037006,China)

机构地区：[1]山西中医药大学中药学院,山西晋中030619 [2]大同市食品药品检验检测中心,山西大同037006

出　　处：《中国医院用药评价与分析》2019年第1期66-68,71,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:建立一测多评法进行疏风清热胶囊中5种蒽醌类成分的含量测定。方法:采用高效液相色谱法,以大黄素为内参物,确立其与芦荟大黄素、大黄酸、大黄酚和大黄素甲醚的相对校正因子,并与外标法测定结果进行比较,以验证一测多评法在测定该成分的合理性和可行性。结果:10批样品中,一测多评法计算值与外标法实测值相对误差无明显差异。结论:本方法准确可靠,可用于疏风清热胶囊中5种蒽醌类成分的含量测定。OBJECTIVE:To establish a method for the content determination of five anthraquinones in Shufengqingre capsules by quantitative analysis multi-components by single marker(QAMS).METHODS:HPLC was adopted and emodin was set as an internal reference substance to establish the relative correction factors of aloe-emodin,rhein,chrysophanol and emodin monomethyl ether,which were compared with the results of external standard method to verify the rationality and feasibility of QAMS.RESULTS:Among the 10 batches of samples,there was no significant difference between the calculated values of QAMS and the measured values of the external standard method.CONCLUSION:This method is accurate and reliable,which can be used for the content determination of five anthraquinones in Shufengqingre capsules.

关 键 词：一测多评 疏风清热胶囊 相对校正因子 蒽醌类成分 

分 类 号：R927.2[医药卫生—药学]