自噬基因AMBRA1在宫颈癌中的表达及其临床意义  

Expression of Autophagy Gene AMBRA1 in Cervical Cancer and its Clinical Significance

作　　者：彭成清[1] 张雪 张力 陈洪雷 Peng Chengqing(Department of Pathology,Basic Medical Science School of Wuhan University,Hubei Province,Wuhan 430071)

机构地区：[1]湖北医药学院 [2]武汉大学基础医学院病理学教研室,武汉430071

出　　处：《数理医药学杂志》2019年第2期159-161,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨自噬基因AMBRA1在宫颈癌中的表达及其与临床病理参数的关系。方法:利用量子点免疫荧光组织化学技术检测自噬基因AMBRA1在组织芯片包括97例宫颈癌组织和15例非癌变宫颈黏膜上皮组织中的表达。结果:AMBRA1蛋白在宫颈癌组织的阳性表达率为54.7%,与非癌变宫颈黏膜上皮组织比较,差异有统计学意义(P<0.05);AMBRA1的阳性表达与宫颈癌组织学类型和TNM分期均显著相关(P<0.05),而与其他临床病理参数均无关(P>0.05)。结论:自噬基因AMBRA1表达缺失可能促进宫颈癌的形成和恶性进展。Objective:To investigate the expression of autophagy gene AMBRA1 in cervical cancer and its relationship with clinicopathological parameters.Methods:Quantum dots immunofluorescence histochemistry was used to detect the expression of autophagy related gene AMBRA1 in tissue microarray including 97 cases of cervical cancer and 15 cases of non-cancerous cervical epithelium.Results:The positive rate of AMBRA1 protein expression in cervical cancer tissues was 54.7%,compared with non-cancerous cervical epithelial tissues,the difference was significant(P<0.05).The positive expression of AMBRA1 was significantly correlated with histological subtype and TNM stage of cervical cancer(P<0.05),but not related with other clinicopathological parameters(P>0.05).Conclusion:The loss of autophagy gene AMBRA1 expression may promote the formation and malignant progression of cervical cancer.

关 键 词：宫颈肿瘤/病理学 AMBRA1 自噬作用 量子点 

分 类 号：R446.8[医药卫生—诊断学]