氢吗啡酮用于腹腔镜手术后患者自控静脉镇痛的效果  

Effects of hydromorphone on patient controlled intravenous analgesia after laparoscopic surgery

作　　者：邓玉辉 DENG Yuhui(Department of Anesthesiology,Nanhai Hospital of Southern Medical University,Foshan 528244,China)

机构地区：[1]南方医科大学南海医院麻醉科,广东佛山528244

出　　处：《中国医药科学》2019年第3期104-106,共3页China Medicine And Pharmacy

摘　　要：目的探讨氢吗啡酮用于腹腔镜手术后患者自控静脉镇痛的效果及应用价值。方法将2016年7月～2017年7月入住我院治疗并拟行腹腔镜手术的136例患者,采用随机数字表法将其分为两组。对照组患者(n=68)予舒芬太尼行自控静脉镇痛,观察组患者(n=68)予盐酸氢吗啡酮行自控静脉镇痛,分析药物镇痛效果及不良反应情况。结果观察组患者术后6、12和24h镇痛评分分别为(3.76±0.38)分、(3.16±0.47)分和(2.31±0.26)分,与对照组相应时间点比较均有明显减少(t=6.345,3.511,14.835,P <0.05);两组患者术后48h镇痛评分比较,差异无统计学意义(t=1.029,P> 0.05)。镇痛期间,观察组患者不良反应发生率(13.24%)明显低于对照组(30.88%),差异有统计学意义(χ~2=6.158,P <0.05)。观察组患者术后镇痛满意率(89.71%)明显高于对照组(67.65%),差异有统计学意义(χ~2=9.861,P <0.05)。结论氢吗啡酮用于腹腔镜手术后患者自控静脉镇痛的效果良好,不良反应较少,极具临床应用和推广价值,可作为临床治疗的首选。Objective To explore the effects of hydromorphone on patient controlled intravenous analgesia after laparoscopic surgery. Methods One hundred and thirty-six patients admitted to our hospital for treatment from July 2016 to July 2017 for laparoscopic surgery were randomly divided into observation group and control group,with 68 patients in each group.The control group received sufentanil,while the observation group received hydromorphone hydrochloride for controlling venous analgesia.The analgesic effect and adverse reactions were analyzed. Results The postoperative analgesia scores at 6,12 and 24h in the observation group were(3.76±0.38),(3.16±0.47)and (2.31±0.26),respectively,which were significantly reduced compared with the corresponding time points in the control group(t=6.345,3.511,14.835,P < 0.05).There was no significant difference in postoperative analgesia score between the two groups 48h after surgery(t=1.029,P > 0.05).During analgesia,the incidence of adverse reactions in the observation group(13.24%)was significantly lower than that in the control group(30.88%),which were significant differences between the two groups(χ2=6.158,P < 0.05).The postoperative analgesia satisfaction rate(89.71%)in the observation group was significantly higher than that in the control group(67.65%),and the difference was statistically significant(χ2=9.861,P < 0.05). Conclusion Hydromorphone is effective in the treatment of patient-controlled intravenous analgesia after laparoscopic surgery,with few adverse reactions,and has great clinical application and promotion value.It can be used as the first choice for clinical treatment.

关 键 词：氢吗啡酮 腹腔镜 自控静脉镇痛 阿片类药物 

分 类 号：R614[医药卫生—麻醉学]