定量MRI评价肝泡型包虫病肝储备功能的初步探讨  

Quantitative MR imaging for assessment of liver function in patients with hepatic alveolar echinococcosis

作　　者：张茜茹 依巴努.阿不都热合曼 王健[2] 蒋奕[2] 刘文亚[2] ZHANG Qian-ru;Yibanu·Abudureheman;WANG Jian(Department of Radiology,Xinjiang Medical University First Hospital,Urumqi 361026,China)

机构地区：[1]厦门市海沧医院,福建361026 [2]新疆医科大学第一附属医院,乌鲁木齐830011

出　　处：《放射学实践》2019年第3期306-310,共5页Radiologic Practice

基　　金：国家自然科学基金(81460280)

摘　　要：目的:探讨磁共振T_1-mapping、T_2-mapping定量评价肝泡型包虫病(HAE)肝功能的临床应用价值。方法:搜集本院行肝脏磁共振T_1-mapping及T_2-mapping扫描的36例HAE患者(病例组)和20例肝脏功能正常的健康志愿者(对照组)。根据Child-Pugh分级评分将病例组分为肝功能A级组(n=14)、B级组(n=12)和C级组(n=10)。分别测量肝泡型包虫病例组及对照组正常肝实质的弛豫时间,得到T_1值和T_2值,采用方差分析两两比较四组间T_1、T_2值。结果:对照组T_1值为(338.9±95.6)ms,T_2值为(42.7±3.1)ms;病例A组T_1值为(393.47±158)ms,T_2值为(43.74±5.3)ms;B组T_1值为(351.5±84.7)ms,T_2值为(57.85±7.7)ms;C组T_1值为(460.9±76.0)ms,T_2值为(65.9±3.0)ms。各组间T_1值差异均无统计学意义(P>0.05),对照组T_2值与病例A组差异无统计学意义(P>0.05),对照组与病例B组、C组及病例组A、B、C各组间差异有统计学意义(P<0.05)。结论:肝泡型包虫病例随肝功能C-P分级不同,其T_2值存在差异,磁共振T_2-mapping成像有望用于定量评价肝脏储备功能,为临床医师评估肝泡型包虫肝脏储备功能提供一种新的手段。T_1值定量评价HAE肝功能仍需论证。Objective:The purpose of this study was to assess the clinical application value of T1-mapping and T2-mapping MR scan for assessment of liver function in patients with hepatic alveolar echinococcosis (HAE). Methods:36 patients with HAE (male 17,female 19 ) and 20 volunteers (male 10,female 10) underwent both T1 and T2-mapping scan.20 cases of control group and HAE groups were divided into three groups according to Child-Pugh score:group A (n=14),group B (n=12),group C (n=10).T1 and T2 values were measured by Siemens workstation in residual liver parenchyma of HAE group and in liver parenchyma of control group. The variance analysis was used to compare the T1 and T2 values between the four groups. Results:The measurements of T1 and T2 average values were as below:control group [T1 (338.9±95.6)ms,T2 (42.7±3.1)ms];group A [T1 (393.47± 158)ms,T2 (43.74±5.3)ms];group B [T1 (351.5±84.7)ms,T2 (57.85±7.7)ms];group C [T1 (460.9±76.0)ms,T2 (65.9±3.0)ms].There was no statistically significant difference found in T1 values between the 4 groups ( P >0.05).However,T2 values were statistically significant differences between the control group and group B and C ( P <0.05),and between group A and B and C ( P < 0.05), however,but no significant difference in T2 velues between healthy group and group A ( P > 0.05). Conclusion:T2-mapping sequence may be useful for the assessment of liver function of HAE,while T1-mapping sequence still need to investigate.

关 键 词：磁共振成像 肝功能 包虫病 肝 

分 类 号：R445.2[医药卫生—影像医学与核医学] R532.32[医药卫生—诊断学]