吡咯里西啶生物碱毒性作用研究进展  

Research Progress on Toxicity of Pyrrolizidine Alkaloids

作　　者：孙潇翔 向娥 邱帅凯 汪晖[1,2] 郭喻 SUN Xiaoxiang;XIANG E;QIU Shuaikai;WANG Hui;GUO Yu(Department of Pharmacology, School of Basic Medical Science, Wuhan University, Hubei Wuhan 430071, China;Hubei Provincial Key Laboratory of Developmentally Originated Disease, Hubei Wuhan 430071, China)

机构地区：[1]武汉大学基础医学院药理学系,湖北武汉430071 [2]发育源性疾病湖北省重点实验室,湖北武汉430071

出　　处：《中国药物警戒》2019年第2期76-80,共5页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金(81473290):吡咯里西啶生物碱致母;胎肝毒性差异及其代谢活化机制;国家自然科学基金青年项目(30901835):胎肾上腺CYP3A介导吡咯双环生物碱类发育毒性的代谢损伤机制;中央高校基本科研业务费专项(2042017Kf1032):吡咯里西啶生物碱致发育毒性的性别差异及其机制研究

摘　　要：吡咯里西啶生物碱(pyrrolizidine alkaloids,PAs)是一类广泛分布于世界各地植物中的天然成分,其中部分种类具有抗肿瘤、抗菌等功效。但大部分PAs的氮氧化物(pyrrolizidine alkaloid N-oxides,PANO)及PAs的代谢活化产物脱氢吡咯里西啶生物碱(dehydropyrrolizidine alkaloids,DHPA)具有多种毒性作用,可导致多脏器损伤、致癌和致发育毒性等。PAs的毒性作用已逐渐引起大众的广泛关注,本研究对近年来PAs的毒性机制、解毒途径及其典型毒性作用的研究进展进行综述。Pyrrolizidine alkaloids (PAs) are a group of natural components which widely distributed in plants all over the world. Some of them have anti-tumor and anti-bacterial effects. However, most PAs exert multiple toxicities after metabolic activation, while toxicities of pyrrolizidine alkaloid N-oxides (PANO) have been reported in recent years. They attack multiple organs, induce carcinomas and cause developmental toxicity. This review updated the research on mechanism and effect of PAs toxicity as well as detoxification during recent years.

关 键 词：吡咯里西啶生物碱 代谢活化 发育毒性 

分 类 号：R961[医药卫生—药理学]