雄激素受体对多囊卵巢综合征患者生育能力的影响  

Effects of androgen receptor on fertility in patients with polycystic ovary syndrome

作　　者：林少梅 邢彦君 刘佩姬 LIN Shaomei;XING Yanjun;LIU Peiji(Department of Obstetrics and Gynecology,ShundeWomen’s and Children’s Hospital of Guangdong Medical University,Foshan528300,China)

机构地区：[1]广东医科大学附属顺德妇女儿童医院妇产科,广东佛山528300

出　　处：《汕头大学医学院学报》2019年第1期28-30,共3页Journal of Shantou University Medical College

摘　　要：目的:研究雄激素受体(androgen receptor,AR)对多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者生育能力的影响。方法:选取广东医科大学附属顺德妇女儿童医院2016年8月至2018年8月收治的因不孕、PCOS行卵巢楔形切除患者卵巢病理组织26例为观察组,选择同期非PCOS患者于卵泡期行手术取得的正常卵巢组织15例为对照组。比较2组患者各级卵泡的数目,同时比较各卵泡颗粒细胞中AR的阳性率和2组患者的生育能力。结果:观察组患者的初级卵泡、次级卵泡、窦卵泡数量明显高于对照组,差异均有统计学意义(P <0.05),而AR阳性率、始基卵泡与闭锁卵泡数量与对照组相比,差异均无统计学意义(P> 0.05);观察组患者未曾受孕比例显著高于对照组(P <0.05),AR在窦卵泡中表达最明显。结论:AR可间接降低PCOS患者的生育能力,抑制卵泡的生长发育,进而减少了患者卵巢产生成熟卵细胞的可能性。Objective: To study the effect of androgen receptor (AR) on fertility in patients with polycystic ovary syndrome (PCOS). Methods: Ovarian biopsy specimens were collected from 26 selected infertile patients with polycystic ovary syndrome who underwent ovarian wedge resection in Shunde Women’s and Children’s Hospital of Guangdong Medical University between August 2016 and August 2018. Over the same period, specimens were collected from a control group of 15 non-PCOS patients who received ovarian wedge resection during the follicular phase. The number of follicles at each stage, the positive rate of androgen receptor in granulosa cells and the fertility were compared between the two groups. Results: The number of primary follicles, secondary follicles and antral follicles in the treatment group was significantly higher than that in the control group (P < 0.05), but there was no significant difference in AR positive rate, primordial follicle and atresia follicles compared with the control group (P > 0.05). The proportion of patients who had never conceived in the treatment group was significantly higher than that in the control group (P < 0.05), and AR was prominently expressed in antral follicles. Conclusion: Androgen receptor can significantly reduce the fertility of patients with polycystic ovary syndrome and inhibit the growth and development of follicles, thus hindering the ovary from releasing mature eggs. These findings are of great significance to the clinical diagnosis and treatment of PCOS-induced infertility.

关 键 词：雄激素 多囊卵巢综合征 生育能力 卵泡颗粒细胞 受体 

分 类 号：R711.75[医药卫生—妇产科学]