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作 者:庄凤娟[1] 郑艳[1] 陈艳[1] ZHUANG Fengjuan;ZHENG Yan;CHEN Yan(Shiyan Renmin Hospital,Renmin Hospital Affiliated to Hubei University of Medicine,Shiyan 442000,Hubei,China)
机构地区:[1]十堰市人民医院/湖北医药学院附属人民医院,湖北十堰442000
出 处:《中西医结合心脑血管病杂志》2019年第2期229-233,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基 金:湖北省教育厅人文社会科学基金项目(No.16Y124);湖北省教育厅科研计划项目(No.B2016503)
摘 要:目的系统评价丹参川芎嗪注射液联合曲美他嗪治疗不稳定型心绞痛的临床疗效。方法通过检索PubMed、Cochrane Library、EMbase、PEDro、NTIS、CNKI、WanFang Data、VIP等数据库,检索所有关于丹参川芎嗪注射液联合曲美他嗪治疗不稳定型心绞痛的随机对照试验(RCTs),采用RevMan5.3软件进行Meta分析。结果纳入12篇文献,1 015例病人。丹参川芎嗪注射液联合曲美他嗪可显著提高不稳定型心绞痛的临床疗效[OR=5.01,95%CI(3.37,7.46)],有效减少心绞痛发作次数[MD=-1.16,95%CI(-1.45,-0.86)],缩短疼痛时间[MD=-4.52,95%CI(-6.35,-2.68)],降低硝酸甘油用量[MD=-0.93,95%CI(-1.49,-0.38)]。结论丹参川芎嗪注射液与曲美他嗪联合用药可显著改善不稳定型心绞痛的治疗效果。Objective To systematically evaluate the efficacy of Salviae Miltiorrhizae and Ligustrazine hydrochloride injection combined with trimetazidine in the treatment of unstable angina pectoris.Methods The randomized controlled trials(RCTs)Salviae Miltiorrhizae and Ligustrazine hydrochloride injection combined with trimetazidine for unstable angina pectoris were retrieved from PubMed,Cochrane Library,Embase,PEDro,NTIS,China National Knowledge Infrastructure(CNKI),and Wanfang database,VIP databases.Meta-anaIysis was performed by RevMan 5.3 software.Results Tweleve RCTs were enrolled,with 1 015 patients.Meta-analysis showed that Salviae Miltiorrhizae and Ligustrazine hydrochloride injection combined with trimetazidine could significantly improve the clinical efficacy[OR=5.01,95%CI(3.37,7.46)],effectively reduce the frequency of angina pectoris[MD=-1.16,95%CI(-1.45,-0.86)],shorten the time of pain[MD=-4.52,95%CI(-6.35,-2.68)],reduce the dosage of nitroglycerin[MD=-0.93,95%CI(-1.49,-0.38)].Conclusion Salviae Miltiorrhizae and Ligustrazine hydrochloride injection combined with trimetazidine can significantly improve the therapeutic effect of unstable angina pectoris.
关 键 词:不稳定型心绞痛 丹参川芎嗪注射液 曲美他嗪 META分析 心绞痛
分 类 号:R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]
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