辛伐他汀对血脂异常绝经糖尿病女性骨密度及上肢骨折愈合的影响  

Effects of Simvastatin on Bone Mineral Density and Fracture Healing in Postmenopausal Women with Abnormal Blood Lipid Metabolism

作　　者：刘晓宁[1] 鞠阳[1] 孔德明[1] 仝超[1] 银晓永 张磊[1] 王浩军[1] 肖继龙 Liu Xiaoning;Ju Yang;Kong Deming(First Orthopedic Department,Handan Branch,Hospital of Jizhong Energy Group,Handan 056001,China)

机构地区：[1]冀中能源峰峰集团总医院邯郸院区骨一科,河北邯郸056001

出　　处：《实用骨科杂志》2019年第3期220-222,共3页Journal of Practical Orthopaedics

基　　金：河北省卫计委青年科技课题(20160743)

摘　　要：目的探讨血脂代谢异常绝经后糖尿病女性应用辛伐他汀(20mg/d)进行降脂治疗时,对上肢骨折患者术后骨密度及骨折愈合的影响。方法随访86例上肢骨折的血脂代谢异常绝经后糖尿病女性患者,依据患者是否服用降脂药物辛伐他汀(20mg/d)治疗分为对照组和治疗组,比较两组患者在院期间及术后3月健侧桡骨远端骨密度及骨折愈合的差异。结果在院期间治疗组与对照组健侧桡骨远端1/3处骨密度相比差异无统计学意义(P>0.05)。治疗3个月后,治疗组骨密度与治疗前相比差异无统计学意义(P>0.05);对照组骨密度与治疗前相比差异无统计学意义(P>0.05);治疗3个月后治疗组与对照组两组间骨密度差异无统计学意义(P>0.05)。治疗组与对照组相比骨折愈合人数差异无统计学意义,降脂治疗剂量的辛伐他汀(20mg/d)没有体现出具有促进骨折愈合的作用。结论血脂代谢异常绝经后糖尿病骨折女性,在应用辛伐他汀(20mg/d)进行降脂治疗3个月期间,对桡骨远端骨密度及骨折愈合没有影响。Objective To investigate the effects of simvastatin (20 mg/d) on bone mineral density and fracture healing in dyslipidemia diabetes patients with upper extremity fractures. Methods 86 cases of postmenopausal women with diabetes mellitus with abnormal blood lipid metabolism were followed up.According to whether the patients took the lipid-lowering drug simvastatin (20mg/d),they were divided into the control group and the treatment group.The difference of bone mineral density and fracture healing in the distal tibia of the healthy side in the last 3 months. Results During the hospital,there was no significant difference in bone mineral density of the radius between the treatment group and the control group ( P >0.05).After 3 months of treatment,the treatment group bone density compared with before treatment showed no significant difference( P >0.05);the control group mean bone density increased,but no significant difference before and after treatment ( P >0.05).After 3 months of treatment,there was no significant difference in bone mineral density ( P >0.05) between the treatment group and the control group.There were no significant differences in the number of fracture healing between the treatment group and the control group.Simvastatin(20 mg/d) does not promote the healing of fracture in postmenopausal diabetes women with hyperlipidemia. Conclusion Simvastatin(20mg/d) has no effect on bone mineral density in the distal radius and fracture healing in hyperlipidemia postmenopausal diabetes mellitus patients with upper extremity fractures.

关 键 词：辛伐他汀 糖尿病 骨折 骨密度 血脂代谢异常 绝经 

分 类 号：R683.41[医药卫生—骨科学]