海洛因成瘾者渴求任务对大型脑网络影响的功能磁共振研究  

Functional magnetic resonance imaging study on the effects of craving task on large-scale brain networks in heroin addicts

作　　者：时宏 陈佳杰 王帆 刘为 刘洁蓉 薛久华 魏璇 李玮 朱佳 李强 王玮 SHI Hong;CHEN Jiajie;WANG Fan;LIU Wei;LIU Jierong;XUE Jiuhua;WEI Xuan;LI Wei;ZHU Jia;LI Qiang;WANG Wei(Radiology Department of Tangdu Hospital,Air Force Military Medical University,Xi'an,710038,China)

机构地区：[1]空军军医大学唐都医院放射科,西安710038

出　　处：《磁共振成像》2019年第3期161-168,共8页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:81671661;81771813)~~

摘　　要：目的探讨海洛因成瘾者在毒品线索任务下主观渴求及大型脑网络特征。材料与方法 21例海洛因成瘾者与33例年龄、性别、教育程度相匹配的健康者,纳入该功能磁共振成像(functional MRI,fMRI)研究。应用Matlab、SPM8、DPABI及SPSS 20.0软件进行数据分析。首先,基于静息态fMRI的数据获取任务负相关网络及任务正相关网络;然后,进行事件相关毒品线索下的任务态fMRI,并对其大脑网络的差异行组间比较,继而与其心理行为学行相关性分析。结果海洛因成瘾者在毒品线索刺激任务后渴求程度显著性大于任务前(t=1.19,P=0.00);正常对照组此项对比无显著性差异(t=0.031,P=0.75)。与正常组相比,海洛因成瘾在毒品线索任务下,任务负相关网络(默认网络)及任务正相网络(突显网络、执行控制网络、高级视觉网络、视觉空间网络、基底核团)激活强度均显著增强(P<0.05,AphaSim校正),而任务正相关网络的初级视觉网络激活程度显著降低(P<0.05,AphaSim校正)。控制头动因素,海洛因成瘾者大脑基底核团激活强度与观看毒品相关线索后的渴求程度成正相关关系(r=0.56,P=0.01)。结论海洛因成瘾者心理渴求及在毒品线索条件下任务相关正、负大型脑网络功能均存在明显异常。Objective:To investigate the changes of subjective craving and characteristics of large-scale brain networks in heroin addicts during the drug cues task.Materials and Methods:Twenty-one heroin addicts and 33 healthy subjects matched by age,sex and education level were included in this study.Analysis of imaging and behavioral difference were carried out with Matlab,SPM8,DPABI and SPSS 20.0 software.The templates of task-negative network and task positive network were obtained from the resting state functional magnetic resonance data,and the differences in drug cue induced brain response within these networks were analyzed,and then the correlation analysis with psychological behavior was performed.Results:The craving score of heroin addicts after stimulation of drug cues was significantly higher than that of before the task(t=1.19,P=0.00),but no significant difference was found in normal control group(t=0.031,P=0.75).Compared with the normal group,the heroin addicts showed higher activation of task negative network(default mode network)and task positive network(salient network,executive control network,higher vision network,visuospatial network,basal ganlia)(P<0.05,AphaSim corrected).However,the response of primary visual network in taskpositive network was lower in heroin addiction group relative to normal control group(P<0.05,AphaSim corrected).Controlling the head movement factor,the activation of basal nuclei in heroin addicts was positively correlated with the craving score after drug cue exposure(r=0.56,P=0.01).Conclusions:The large-scale brain networks of heroin addicts is commonly abnormal when exposed to drug related cues.

关 键 词：海洛因依赖 渴求 神经通路 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R745.1[医药卫生—诊断学]