尼可地尔联合前列地尔注射液治疗顽固性心绞痛的疗效分析  

Clinical effect of nicorandil combined with alprostadil injection in the treatment of intractable angina

作　　者：王森[1] 刘玲玲 刘奕[1] 冯春光[1] 韩冰[1] WANG Sen;LIU Lingling;LIU Yi;FENG Chunguang;HAN Bing(Department of Cardiology,Xuzhou Central Hospital,Xuzhou,Jiangsu 221009,China)

机构地区：[1]徐州市中心医院心内科,江苏徐州221009

出　　处：《安徽医药》2019年第4期692-695,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨尼可地尔联合前列地尔注射液治疗顽固性心绞痛临床疗效。方法选择2015年12月至2107年4月徐州市中心医院顽固性心绞痛120例,采用简单随机化分组的方式分为尼可地尔组(n=42),前列地尔注射液组(n=38)以及尼可地尔联合前列地尔注射液组(n=40)。三组病人在常规心绞痛药物治疗基础上,分别加用尼可地尔、前列地尔注射液、尼可地尔联合前列地尔注射液,观察三组病人用药前后心绞痛发作情况及6 min步行试验改善情况。结果 2周治疗后,三组病人心绞痛发作情况及6 min步行试验较用药前均有显著改善,尼可地尔联合前列地尔注射液组在心绞痛有效率上改善较明显(87.50%比57.89%,87.50%比64.29%,χ~2=8.681、5.987,均P<0.017),6 min步行试验上改善明显(F=17.614,P<0.001),差异有统计学意义。结论对于顽固性心绞痛病人,在常规抗心绞痛药物治疗的基础上,联合使用尼可地尔和前列地尔注射液可改善心绞痛发作及提高运动耐量。Objective To observe the effects of the nicorandil combined with alprostadil injection in the treatment of intractable angina.Methods One hundred and twenty patients diagnosed by coronary arteriography or tomography angiography in Xuzhou Central Hospital from December 2015 to April 2017 were random allocated into three groups by the simple randomization,including the nicorandil group(n=42),the alprostadil injection group(n=38),and the nicorandil combined with alprostadil injection group(n=40).On the basis of conventional angina pectoris treatment,the nicorandil group was treated with nicorandil,the alprostadil injection group was treated with alprostadil,while the nicorandil combined with alprostadil injection group was treated with nicorandil combined with alprostadil.Changes of angina frequency and 6 minute walking test in these three groups before and after treatment were observed.Results After 2 weeks of treatment,the chest pain symptoms and 6 minute walking test in three groups were significantly improved.Effective rate of chest pain symptom and 6 minute walking test were significantly improved in the group of nicorandil combined with alprostadil injection,and the difference was statistically significant(87.50%vs.57.89%,87.50%vs.64.29%,χ^2=8.681,5.987,P<0.017;F=17.614,P<0.001).Conclusion On the basis of conventional therapy,the treatment of intractable angina with nicorandil combined with alprostadil can ease the chest pain,and significantly improve exercise tolerance.

关 键 词：心绞痛 尼可地尔 前列地尔 治疗结果 

分 类 号：R541.4[医药卫生—心血管疾病]