药品不良反应报告147例的回顾性分析  

Retrospective analysis of 147 cases of adverse drug reactions

作　　者：张强 ZHANG Qiang(Medical Department,Nanjing Gulou Hospital Group Anqing Petrochemical Hospital,Anqing,Anhui 246001,China)

机构地区：[1]南京鼓楼医院集团安庆市石化医院医务科,安徽安庆246001

出　　处：《安徽医药》2019年第4期846-848,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的掌握南京鼓楼医院集团安庆市石化医院药品不良反应(ADR)发生的特点和规律。方法利用Excel,回顾性分析2011年1月至2013年12月上报的147例药品不良反应报告。结果 147例ADR报告中,A型不良反应有140例,占95.24%,B型不良反应有7例,占4.76%,无C型不良反应。60岁以上老年病人所占比例最高,为41.50%;给药途径中,静脉给药所占比例最高,为81.63%;涉及药品种类中,抗感染药物所占比例最高,为49.66%;临床表现以皮肤及其附件损害最多,为42.18%;上报科室以呼吸内科最多,为38.78%;上报人以临床医师最多,为75.51%。结论 ADR的发生不可完全避免,但是在临床实践中,因不合理用药导致的A型不良反应(有140例,占95.24%)却占有重要比例。要提升药师的药学服务能力,促进药学监测工作的开展,才能确保病人用药安全,做到合理用药。Objective To master the characteristics and regularity of adverse drug reactions(ADR)in Nanjing Gulou Hospital Group Anqing Petrochemical Hospital.Methods One hundred and forty-seven adverse drug reactions reported from January 2011 to December 2013 was retrospectively analyzed using Excel.Results Among the 147 cases of ADR,there were 140 cases of type A adverse reactions,accounting for 95.24%,there were 7 cases of B type adverse reactions,accounting for 4.76%,and there was no C type adverse reaction.Patients older than 60 years accounted for the highest proportion of 41.50%;the route of administration,the proportion of intravenous administration was the highest(81.63%);involving the types of drugs,anti-infective drugs accounted for the highest proportion of 49.66%;the clinical manifestations of the damage of skin and its appendages were most,accounting for 42.18%;Department of Respiratory Medicine was the most frequently reported department(38.78%),clinicians was the most reported people(75.51%).Conclusions The occurrence of ADR cannot be completely avoided,but in clinical practice,the A type adverse reactions caused by irrational use of drugs occupy an important proportion(140 cases,accounting for 95.24%).To improve the pharmaceutical service ability of pharmacists and promote the development of pharmaceutical monitoring,it is necessary to ensure the safety of patients medication and rational use of drugs.

关 键 词：药物毒性 药物处方 处方不当 药物监测 物副反应报告系统 

分 类 号：R95[医药卫生—药学]