川芎嗪注射液联合低分子肝素对慢性肺心病急性加重期患者炎性因子及凝血功能的影响  

Effect of ligustrazine injection combined with low molecular weight heparin on the inflammatory factors and coagulation function in patients with acute exacerbation of chronic pulmonary heart disease

作　　者：詹鑫亮 张燕妮[2] 蒋林 陶莹[1] ZHAN Xin-liang;ZHANG Yan-ni;JIANG Lin;TAO Ying(Department of Respiratory Medicine,Huangmei County People's Hospital of Huanggang City,Huanggang,Hubei 435500,China)

机构地区：[1]黄冈市黄梅县人民医院呼吸内科,湖北黄冈435500 [2]黄冈市黄梅县人民医院心血管内科,湖北黄冈435500

出　　处：《临床肺科杂志》2019年第4期672-675,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨川芎嗪注射液联合低分子肝素对慢性肺心病急性加重期患者血清炎性因子及凝血功能的影响。方法选择2015年10月-2016年12月收治的慢性肺心病急性加重期患者124例为研究对象,采用随机数字表法分为观察组各对照组各62例。对照组给予西医常规治疗,观察组联合给予川芎嗪注射液、低分子肝素治疗。治疗2周后,比较两组血清炎性因子、凝血功能、不良反应、临床疗效等指标。结果观察组有效率93.55%明显高于对照组79.03%(χ~2=5.522,P<0.05);血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)含量明显低于对照组(t=7.010, 13.738, 17.448,P<0.05,P<0.01);凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)明显低于对照组(t=11.552, 4.635, 6.407,P<0.05,P<0.01);两组不良反应比较无统计学意义(9.68%vs 6.45%)(χ~2=0.435,P>0.05)。结论川芎嗪注射液联合低分子肝素治疗有助于提高慢性肺心病急性加重期患者临床疗效,可能与抑制患者炎症状态、改善凝血功能等因素有关。Objective To investigate the effect of ligustrazine injection combined with low molecular weight heparin on serum inflammatory factors and blood coagulation function in patients with acute exacerbation of chronic cor pulmonale.Methods 124 patients with acute exacerbation of chronic cor pulmonale from October 2015 to December 2016 were selected as the subjects,and they were randomly divided into the observation group and the control group with 62 cases in each group.The control group was given conventional treatment with western medicine,and the observation group was combined with ligustrazine injection and low molecular weight heparin.After 2 weeks of treatment,the serum inflammatory factors,blood coagulation function,adverse reaction and clinical efficacy of the two groups were compared.Results The effective rate of the observation group was 93.55%,significantly higher than 79.03% in the control group(χ^2=5.522,P<0.05).Serum interleukin-8(IL-8),tumor necrosis factor alpha(TNF-alpha),and high sensitive C reactive protein(hs-CRP)were significantly lower in the observation group than in the control group(t=7.010,13.738,17.448,P<0.05,P<0.01).Prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)were significantly lower in the observation group than in the control group(t=11.552,4.635,6.407,P<0.05,P<0.01).The adverse reactions of the two groups was not statistically significant(9.68% vs 6.45%)(χ^2=0.435,P>0.05).Conclusion Ligustrazine injection combined with low molecular weight heparin therapy is helpful to improve the clinical efficacy of patients with acute exacerbation of chronic cor pulmonale,which may be related to inhibiting the inflammatory state and improving coagulation function.

关 键 词：慢性肺心病急性加重期 川芎嗪注射液 低分子肝素 炎性因子 凝血功能 

分 类 号：R541.5[医药卫生—心血管疾病]