慢性心力衰竭血清甲状腺激素变化临床意义分析  

Clinical Significance of Serum Thyroid Hormone Changes in Chronic Heart Failure

作　　者：赵萍[1] ZHAO Ping(Department of Cardiology,Third People's Hospital of Nantong City,Nantong,Jiangsu Province,226000 China)

机构地区：[1]南通市第三人民医院心内科,江苏南通226000

出　　处：《系统医学》2019年第2期33-35,共3页Systems Medicine

摘　　要：目的探讨慢性心力衰竭血清甲状腺激素水平变化的临床意义。方法选取该院2016年1月—2017年12月124例心力衰竭患者为观察组,同期124例健康体检作为对照组,对120例心力衰竭患者实施常规治疗,比较观察组及对照组、不同心功能分级患者、心衰死亡与存活组血清甲状腺激素水平差异。结果 124例慢性心力衰竭患者38例(30.65%,38/124)存在不同程度血清甲状腺激素异常,慢性心力衰竭组FT3(2.19±0.71)pg/mL低于健康体检组(4.13±0.92)pg/mL(t=5.08,P<0.05),FT4、TSH比较差异无统计学意义(t=0.97,1.13,P>0.05)。不同心功能分级FT3、FT4比较具有显著性差异,随着心功能分级上升,FT3、FT4下降明显(t=3.35,2.80,P<0.05),TSH比较无差异(t=0.86,P>0.05)。124例患者中死亡10例,死亡组FT3(1.74±0.47)pg/mL、FT4(0.92±0.15)pg/mL均低于存活组(2.39±0.97)pg/mL、(1.16±0.22)pg/mL(t=3.48,2.97,P<0.05),TSH比较差异无统计学意义(t=0.77,P>0.05)。结论甲状腺激素水平对判断心力衰竭患者心力衰竭程度有一定临床价值,FT3可作为心力衰竭患者病情评估和预后判断指标。Objective To investigate the clinical significance of serum thyroid hormone levels in patients with chronic heart failure.Methods From January 2016 to December 2017,124 patients with heart failure were enrolled in the observation group.In the same period,124 healthy physical examinations were used as the control group.120 patients with heart failure were treated routinely.The observation group and the control group were different in serum thyroid hormone levels between functionally graded patients,heart failure and survival groups.Results Of the 124 patients with chronic heart failure,38 case(30.65%,38/124)had different degrees of serum thyroid hormone abnormalities.In the chronic heart failure group,FT3(2.19±0.71)pg/mL was lower than the healthy examination group(4.13±0.92)pg/mL(t=5.08,P<0.05),there was no statistically significan difference in FT4 and TSH(t=0.97,1.13,P>0.05).The FT3 and FT4 of different cardiac function grades were significantly different.With the increase of cardiac function,FT3 and FT4 decreased significantly(t=3.35,2.80,P<0.05),and there was no statistically significan difference in TSH(t=0.86,P>0.05).Of the 124 patients,10 died.The FT3(1.74±0.47)pg/mL and FT4(0.92±0.15)pg/mL were lower in the death group than in the survival group(2.39±0.97)pg/mL,(1.16±0.22)pg/mL(t=3.48,2.97,P<0.05),there was no statistically significan difference in TSH(t=0.77,P>0.05).Conclusion The level of thyroid hormone has certain clinical value in judging the degree of heart failure in patients with heart failure.FT3 can be used as an indicator of disease assessment and prognosis in patients with heart failure.

关 键 词：心力衰竭 甲状腺激素 临床意义 

分 类 号：R541.6[医药卫生—心血管疾病]