ANA、ds-DNA抗体联合检测自身免疫病的临床研究  

Clinical study of combined detection of autoimmune disease with ANA, ds-DNA antibody

作　　者：李春江 张健 石福龙 刘晓彤 王蕊 Li Chunjiang;Zhang Jian;Shi Fulong;Liu Xiaotong;Wang Rui(Shenyang Dean Medical Laboratory Co,Ltd,Shenyang,Liaoning,110141,China)

机构地区：[1]沈阳迪安医学检验所有限公司,辽宁沈阳110141

出　　处：《当代医学》2019年第10期4-6,共3页Contemporary Medicine

基　　金：辽宁省教育厅资助课题(202153324)

摘　　要：目的探讨ANA、ds-DNA抗体联合检测自身免疫病的临床作用。方法回顾性分析在某院确诊的167例自身免疫系统疾病患者的临床检验资料,将其作为研究组,同时选取某院同期检测的167健康体检者作为对照组,两组患者均进行ANA、ds-DNA、ACA、AVYA抗体检测,并针对检测结果进行分析研究。结果 (1)160例各种自身免疫系统疾病患者检测结果显示,在ANA、ds-DNA、ACA、AVYA抗体检测中,在系统性红斑狼疮(SLE)患者中ANA阳性率最高,阳性率为98.00%;ACA抗体在系统性硬皮病(SSc)患者中阳性率最高,阳性率为81.81%;ACYA抗体在皮肌炎(PM/DM)患者中阳性率最高,阳性率为55.56%;ds-DNA抗体在系统性红斑狼疮(SLE)患者中阳性率最高,阳性率为68.00%。(2)122例ANA阳性结果分布情况为均质性(H)以混合性结蹄组织病(MCTD)患者中最多,共16例;斑点型(S)和核周型(M)以SLE患者居多,分别为20例与12例,核仁型(N)以SSr患者最多,共6例。(3)20例ACYA阳性结果分布情况为均质性最多,共12例均为SLE患者,斑点型8例,纤维性无例数。结论应用ANA、ds-DNA、ACA、AVYA抗体检测在自身免疫病患者检测中具有提高阳性检出率的互补性作用,对自身免疫疾病的分类和治疗与预后有重要的价值。Objective To investigate the clinical role of ANA, ds-DNA antibody in the detection of autoimmune diseases. Methods The clinical data of 167 patients with autoimmune system diseases diagnosed in our hospital were retrospectively analyzed as the study group, and the control group was selected as the control group. The patients in both groups were treated with ANA, ds-DNA, ACA. AVYA antibody was detected, and the results were analyzed. Results ①The positive rate of ANA was the highest in (SLE) patients with systemic lupus erythematosus (SLE), and the positive rate was 98.00% among 160 patients with various autoimmune diseases. The positive rate of ACA antibody was the highest in (SSc) patients with systemic scleroderma, and the positive rate was 81.81%. The positive rate was 55.56% in patients with dermatomyositis (PM/DM). The positive rate of ds-DNA antibody is the highest in (SLE) patients with systemic lupus erythematosus.②The distribution of ANA positive results in 122 cases with mixed hoof tissue disease was 68.00%. The distribution of ANA positive results was the highest among the patients with mixed hoof tissue disease (MCTD), 16 of them were homogenous (H). The majority of SLE and peripheral (M) were SLE in 20 cases and 12 cases in peripheral type (M), and 6 cases of nucleolar type (N) in SSr patients.③The distribution of ACYA positive results in 20 cases was the most homogeneous, 12 cases were SLE patients. 8 cases of spotted type, no number of fibrous cases. Conclusion The detection of ANA, ds-DNA, ACA, AVYA antibody can increase the positive rate of autoimmune diseases in patients with autoimmune diseases and play an important role in the classification, treatment and prognosis of autoimmune diseases.

关 键 词：ANA ds-DNA抗体联合 自身免疫病 系统性红斑狼疮(SLE) 

分 类 号：R593.2[医药卫生—内科学] R446.6[医药卫生—临床医学]