卡前列素氨丁三醇与米索前列醇防治高危孕妇剖宫产术后出血的效果分析  

Carprostol Tromethamine and Misoprostol for Prevention of High-risk Pregnant WomenAnalysis of the Effect of Postpartum Hemorrhage after Cesarean Section

作　　者：刘秋瑾[1] 刘琰[1] 郭迎迎 张俊清[1] 赵予颍 LIU Qiu-qi;LIU Yan;GUO Ying-ying;ZHANG Jun-qing;ZHAO Yu-qi(The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China)

机构地区：[1]郑州大学第三附属医院,河南郑州450052

出　　处：《临床研究》2019年第4期29-30,共2页Clinical Research

摘　　要：目的探讨卡前列素氨丁三醇与米索前列醇防治高危孕妇剖宫产术后出血的效果。方法选择本院在2016年6月～2018年6月期间收治的剖宫产高危孕妇70例,采用随机数字表法将其分为35例A组和35例B组,B组产妇采用米索前列醇塞肛治疗,A组产妇采用卡前列素氨丁三醇肌注治疗,比较两组产妇产后2h、24h的出血量以及出现的恶心呕吐、低热、腹泻、头痛、面色潮红等不良反应情况。结果 A组与B组产妇产后2h出血量分别为(213.3±66.4)mL和(324.5±82.1)mL,产后24h出血量分别为(319.2±101.3)mL和(402.4±121.6)mL,两组数据A组产妇均比B组少,两组比较差异显著(P <0.05)。在不良反应方面,A组产妇出现寒颤、恶心呕吐、头痛各1例,发生率为8.6%,B组出现寒颤、低热、面色潮红各1例,出现恶心呕吐2例,发生率为14.3%,略高于A组,但两组比较无统计学差异(P> 0.05)。结论针对临床剖宫产高危孕妇采用卡前列素氨丁三醇治疗比米索前列醇对产妇产后出血的预防更有效,Objective To investigate the effect of prostaglandin tromethamine and misoprostol on prevention of bleeding after cesarean section in high-risk pregnant women. Methods From June 2016 to June 2018, 70 pregnant women with high risk of cesarean section were selected. 35 cases of group A and 35 cases of group B were randomLy divided into two groups. Group B was treated with misoprostol blocking anus, group A was treated by intramuscular injection of carprostatin amitriol, and group A was treated by intramuscular injection of carprostatin triglyceride. The amount of bleeding at 2 hours postpartum and adverse reactions such as nausea and vomiting low fever diarrhea headache and facial flushing were compared between the two groups. Results The amount of postpartum hemorrhage in group A and group B was (213.3 ±66.4) mL and (324.5 ±82.1) mL, respectively. The volume of postpartum bleeding in group A was (319.2 ±101.3) mL and (402.4 ±121.6) mL, respectively, which was significantly lower than that in group B (P < 0.05). In adverse reactions, 1 case of shivering, 1 case of nausea and vomiting, 1 case of headache, 1 case of shivering, 1 case of low fever, 1 case of facial flashes, 2 cases of nausea and vomiting, and 1 case of nausea and vomiting in group A were found in group B, which were slightly higher than those in group A. But there was no statistical difference between the two groups (P > 0.05). Conclusion Carprostol tromethamine is more effective in the prevention of postpartum hemorrhage in women with high risk of cesarean section.

关 键 词：卡前列素氨丁三醇 米索前列醇 高危孕妇 剖宫产术 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]