邹旭教授治疗老龄心悸的用药规律分析  

Analysis on Professor Zou Xu′s Herbal Administration Experience for Aging Palpitation

作　　者：邱俊龙 王晓丽[2] 许健 王侠[2] Qiu Junlong;Wang Xiaoli;Xu Jian(Guangzhou University of Chinese Medicine,Guangdong,Guangzhou 510405,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中医院,广东广州510120

出　　处：《中国中医急症》2019年第3期398-401,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家中医药管理局重点建设项目:岭南中医学术流派传承(国中医药科技发[2012]27号);广东省中医院科研专项项目(中医二院[2013]233号):岭南邓氏内科流派传承工作室建设项目;广东省中医院科研专项项目(中医二院[2014] 89号):邓铁涛名医工作室建设项目

摘　　要：目的基于中医传承辅助系统(V2.5)探讨邹旭教授治疗老龄心悸的中医用药经验及组方规律。方法收集邹旭教授在广东省中医院2016年6月至2018年6月门诊接诊的老龄心悸病例资料,提取处方,建立数据库,采用该软件集成的规则分析、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法,挖掘分析用药经验。结果纳入患者254例,并录入处方254个,使用中药共297味。确定处方中药物的使用频次和药物之间的关联规则,其中使用频次高于120的中药共28味,使用频次最高的前5味药依次为人参(197)、黄芪(175)、当归(171)、丹参(171)、熟地黄(170),5味药所对应的常用剂量分别为10、30、15、10、120 g;支持度为125,置信度为0.82时,共有药物组合25组,使用频次最高药物组合为麦冬-五味子(141)、人参-五味子(141),设置相关度为8,惩罚度为6,演化出14个药物核心组合及7首新方。结论邹旭教授临证以"补虚泄实"为根本,强调气阴亏虚是老龄心悸发生的根本因素,而痰、湿、瘀是发病的直接因素,临证主张养气阴、祛痰湿、活血通络,并注重协调五脏,尤以调脾护心为重。Objective: To analyze the experience and herbal prescription rules of professor Zou Xu′s in treating aging palpitation by using the traditional Chinese medicine(TCM) inheritance system(V2.5) software. Methods: The prescriptions used for aging palpitation cases at Professor Zou's clinic in the Guangdong Provincial Hospital of Chinese Medicine from June 2016 to June 2017 were collected,and screened to establish a formula database. Based on association rules,revised mutual information,complex system entropy cluster,unsupervised hierarchical clustering and other data mining methods,the principle experience and rules were analyzed and summarized. Results: 254 cases were included,with 254 prescriptions and 297 herbs. The frequency of each herb and association rules of the herbs included in the database were identified. 28 herbs had a frequency of more than 120,and top 5 herbs with high using frequency were Ginseng(197),Astragalus membranaceus(175),Angelica sinensis(171),Salvia miltiorrhiza(171),and Radix rehmanniae(170),whose common clinical dosage was 10,30,15,10,and 20 g,respectively. There were 25 combinations of related herbs with degree of support level of 125 and the confidence level of 0.82. Top 2 herb combinations of high using frequency were Radix ophiopogonis-Schisandra chinensis(141) and Ginseng-Schisandra chinensis(141). With association degree of 8 and punishment degree of 6,14 groups of core herbs combinations and 7 new prescriptions were developed. Conclusion: Professor Zou Xu believes the deficiency of Qi and Yin is the primary cause of aging palpitation,and phlegm,dampness and blood stasis are the predisposing factors. He advocates tonifying Qi and Yin,eliminating phlegm-dampness,activating blood circulation and underlined harmony of the five internal organs with a particular emphasis at coordinating spleen to protect heart.

关 键 词：老龄心悸 中医传承辅助平台 邹旭 用药经验 补虚泄实 

分 类 号：R249.8[医药卫生—中医临床基础]