转铁蛋白、乳酸脱氢酶、胃蛋白酶原Ⅰ和胃泌素在恶性贫血诊断中的价值  

Diagnostic Values of Transferrin,Lactate Dehydrogenase,Pepsinogen Ⅰ and Gastrin in Pernicious Anemia

作　　者：张克波[1] 弓自玉 向焰[1] 王勇[1] 李夏平[1] ZHANG Ke-bo;GONG Zi-yu;XIANG Yan;WANG Yong;LI Xia-ping(Mental Health Center,Guangyuan Fourth People′s Hospital,Guangyuan 610000,China)

机构地区：[1]广元市第四人民医院精神卫生中心,四川广元610000

出　　处：《标记免疫分析与临床》2019年第3期397-401,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨转铁蛋白(transferrin,TRF)、乳酸脱氢酶(lactate dehydrogenase,LDH)、胃蛋白酶原I(pepsinogen,PGI)和胃泌素(Gastrin)在恶性贫血诊断中的价值。方法选取恶性贫血患者、缺铁性贫血患者、非恶性贫血的巨幼红细胞性贫血患者和健康体检者各30例分别为恶性贫血组、缺铁贫血组、巨幼贫血组和对照组,检测4组研究对象转铁蛋白、乳酸脱氢酶、胃蛋白酶原Ⅰ和胃泌素的血清水平。用ROC曲线下面积分析转铁蛋白、乳酸脱氢酶、胃蛋白酶原Ⅰ和胃泌素在恶性贫血诊断中的价值。结果恶性贫血患者血清中的乳酸脱氢酶、胃泌素和转铁蛋白的表达量均明显高于非恶性贫血的巨幼细胞贫血患者、缺铁性贫血和健康体检者(P <0. 05),而胃蛋白酶原Ⅰ的表达量明显低于巨幼细胞贫血患者、缺铁性贫血和健康体检者(P <0.05)。LDH,PGI,Gastrin和TRF在恶性贫血组与缺铁贫血组的诊断灵敏度分别为83%、67%、80%、80%,特异性分别为73%、83%、77%、70%;PGI和transferrin在恶性贫血组与巨幼贫血组的诊断灵敏度分别为80%、56%;特异性分别为73%、93%。结论转铁蛋白,乳酸脱氢酶,胃蛋白酶原Ⅰ和胃泌素可作为诊断恶性贫血的潜在标志物。Objective To investigate the diagnostic values of transferrin(TRF),lactate dehydrogenase(lactate dehydrogenase,LDH),pepsinogen I(pepsinogen,PGI)and Gastrin(Gastrin)in pernicious anemia.Methods A total of 90 patients with pernicious anemia,iron deficiency anemia,non-malignant anemia,or megaloblastic anemia,30 for each,and 30 control from healthy physical examination,were selected as the malignant anemia group,iron deficiency anemia group,giant anemia group and the control group,respectively.We then detected the expression levels of TRF,lactate dehydrogenase,pepsinogen I and Gastrin in the serum of the four groups.The area under the ROC curve was used to analyze the diagnostic value of TRF,lactate dehydrogenase,pepsinogen I and Gastrin in pernicious anemia.Results The expression levels of lactate dehydrogenase,Gastrin and TRF in serum of patients with pernicious anemia were significantly higher than those of non-malignant anemia in megaloblastic anemia,iron deficiency anemia and healthy subjects(P<0.05).The expression of pepsinogen I was significantly lower than that of megaloblastic anemia,iron deficiency anemia and healthy subjects(P<0.05).The sensitivity of LDH,PGI,Gastrin and TRF in the anemia group and the iron deficiency anemia group were 83%,67%,80%and 80%,respectively;and the specificity were 73%,83%,77%and 70%,respectively;The sensitivity of PGI and TRF in the malignant anemia group and the giant anemia group were 80%and 56%,respectively;and the specificity were 73%and 93%respectively.Conclusion TRF,lactate dehydrogenase,pepsinogen I and Gastrin can be used as the potential markers for the diagnosis of pernicious anemia.

关 键 词：转铁蛋白 乳酸脱氢酶 胃蛋白酶原I 胃泌素 恶性贫血 诊断 

分 类 号：R556[医药卫生—血液循环系统疾病] R446.11[医药卫生—内科学]