血清25(OH)D3、超敏C反应蛋白水平与老年2型糖尿病合并骨质疏松的相关性分析  

Correlation Between Serum 25(OH)D3 and High-sensitivity C-reactive Protein Levels and Osteoporosis in Elderly Type 2 Diabetes Mellitus

作　　者：杨志宏[1] 张小妮 王小娟[1] 李芳[1] 杨桂凤[1] YANG Zhi-hong;ZHANG Xiao-ni;WANG Xiao-juan;LI Fang;YANG Gui-feng(Department of Geriatrics,Qinhuangdao First Hospital,Qinhuangdao066004,China;Department of Anesthesiology Resuscitation Room,Qinhuangdao First Hospital,Qinhuangdao066004,China)

机构地区：[1]秦皇岛市第一医院老年病科,河北秦皇岛066004 [2]秦皇岛市第一医院麻醉科复苏室,河北秦皇岛066004

出　　处：《标记免疫分析与临床》2019年第3期502-505,510,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的分析血清25-羟维生素D3[25(OH) D3]、超敏C反应蛋白(hs-CRP)水平与老年2型糖尿病(T2DM)合并骨质疏松的相关性。方法将218例T2DM患者中存在骨质疏松者纳入观察组(n=80),骨量减少者纳入对照组A(n=50),无骨质疏松和骨量减少者纳入对照组B(n=88),另选择同期体检的健康老年人群62例作为健康组,比较各组血清25(OH)D3、hs-CRP水平及骨代谢指标[骨钙素(BGP)、总1型前胶原氨基端延长肽(T-P1NP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)],根据血清25(OH)D3水平将观察组受试者分为25(OH)D3严重缺乏组、缺乏组、不足组,对比三组的血清hs-CRP及骨代谢指标,分析血清25 (OH) D3、hs-CRP、骨代谢指标的相关性。结果观察组血清25 (OH) D3、BGP、T-P1NP水平低于对照组A、对照组B、健康组,观察组血清hs-CRP、β-CTX水平高于其他各组(P <0.05);25(OH) D3水平严重缺乏组血清hs-CRP、β-CTX高于25(OH)D3缺乏组、不足组,而血清BGP、T-P1NP水平低于25(OH) D3缺乏组、不足组(P <0.05),25(OH) D3缺乏组、不足组上述指标比较差异也有统计学意义(P <0.05);老年T2DM合并骨质疏松患者血清25(OH)D3与其BGP、T-P1NP呈正相关,而与hs-CRP、β-CTX呈负相关,hs-CRP与BGP、T-P1NP呈负相关,与β-CTX呈正相关(P <0.05)。结论血清25 (OH) D3、hs-CRP参与T2DM发生与发展,能敏感地反映早期骨代谢情况,预测骨质疏松的发生风险。Objective To analyze the correlation between serum 25-hydroxyvitamin D3[25(OH)D3]and high-sensitivity C-reactive protein(hs-CRP)levels and osteoporosis in elderly type 2 diabetes mellitus(T2DM).Methods A total of 218 T2DM patients were enrolled in the study.Among them,patients with T2DM and osteoporosis were included in the observation group(n=80),while those with osteopenia were included in the control group A(n=50)and those without osteoporosis were included in the control group B(n=88).Another 62 healthy elderly people were selected as the healthy control group at the same time.Serum 25(OH)D3 and hs-CRP levels,as well as the bone metabolism indicators[bone gla protein(BGP),total procollagen type 1 amino-terminal propeptide(T-P1NP),βisomer of the C-terminal telopeptide of typeⅠcollagen(β-CTX)]were compared among groups.Serum hs-CRP and bone metabolism indicators were compared among the serum 25(OH)D3 severe lack group,lack group and insufficiency groups.The correlation of serum 25(OH)D3 and hs-CRP with bone metabolism indicators was then analyzed.Results The levels of serum 25(OH)D3,BGP and T-P1NP in the observation group were lower than those in the control group A,the control group B and the healthy control group.The levels of serum hs-CRP andβ-CTX in the observation group were higher than those of all other groups(P<0.05).The levels of serum hs-CRP andβ-CTX in 25(OH)D3 severe lack group were higher,while levels of serum BGP and T-P1NP were lower than those in the 25(OH)D3 lack group and insufficiency group(P<0.05).There were also statistically significant differences between the 25(OH)D3 lack group and insufficiency group for these markers(P<0.05).Serum 25(OH)D3 was positively correlated with T-P1NP and BGP in elderly patients with T2DM and osteoporosis,but negatively correlated with hs-CRP andβ-CTX.Hs-CRP was negatively correlated with BGP and T-P1NP,and positively correlated withβ-CTX(P<0.05).Conclusion Serum 25(OH)D3 and hs-CRP participate in the development and progression of T2DM.They can sensit

关 键 词：25(OH)D3 超敏C反应蛋白 老年 2型糖尿病 骨质疏松 相关性 

分 类 号：R580[医药卫生—内分泌] R587.2[医药卫生—内科学]