蝎毒素多肽与钠通道特异性结合位点研究进展  

Reserch Progress on Specific Binding Sites of Scorpion Toxin Polypeptides and Sodium Channels

作　　者：章旭日[1,2] 白占涛 刘霞[1,2,3] ZHANG Xu-ri;BAI Zhan-tao;LIU XIA(School of Life Sciences,Yan′an University;Research Center for Peptide Resource Drugs, Yan′an University;Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources/Shaanxi Provincial Key Lab of Red Dates,Yan′an 716000,China)

机构地区：[1]延安大学生命科学学院 [2]延安大学多肽资源药物研究中心 [3]陕西省区域生物资源保育利用工程技术研究中心,陕西延安716000

出　　处：《延安大学学报（自然科学版）》2019年第1期68-72,共5页Journal of Yan'an University：Natural Science Edition

基　　金：国家自然科学基金项目(31760275;31860270);陕西省科技厅项目(2017ZDXM-NY-083;2018ZDCXL-SF-01-04;2018ZDXM-NY-038;2018XCTD-02);陕西省科技创新团队(2017KCT-35);陕西省教育厅项目(15JF034);延安市资源药物研究与开发重点科技创新团队(2015CXTD-06);延安市科技惠民项目(2016HM-01);榆林市科技计划项目(2015CXY-21;2016-15-6);延安大学校级科研项目(YD2015-12)

摘　　要：蝎毒素多肽是一种通道门控调节剂,早先研究发现其通过与离子通道的电压感受域结合影响通道的门控特性。新近研究表明,门控调解剂毒素与离子通道孔区也具有额外结合位点。因此,本文就蝎毒素多肽与钠通道特异性结合位点相关研究展开综述,以梳理门控调节剂毒素的结构与调节功能,为蝎毒素多肽与钠通道结合位点结构与功能的解析提供依据,也为靶向钠通道药物的设计与开发提供参考。The scorpion toxin polypeptide is a gating regulator toxin.Previous studies showed that it affects the gating characteristics of the channel by combining with the voltage-sensing domain(VSD)of the ion channel.However,recent studies showed that the gate mediator toxin and ion channel pore regions also have additional binding sites.This veview summarizes related research progress on scorpion toxin polypeptides and sodium channel-specific binding sites,and provides an analytical basis for the structure and function of the scorpion toxin polypeptide and sodium channel binding sites,as well as provides the reference for the design and development of targeted sodium channel drugs.

关 键 词：蝎毒素多肽 钠通道 结合位点 

分 类 号：Q71[生物学—分子生物学]