口服镇静催眠药中毒患者药物治疗性分析  

Analysis of drug therapy in patients with oral sedation hypnotic drug poisoning

作　　者：马莎莎 韩海霞[2] 高天勤[2] 刘莉[2] MA Shasha;HAN Haixia;GAO Tianqin;LIU Li(Binzhou Medical University,Binzhou 256600,China;Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院,山东滨州256600 [2]滨州医学院附属医院,山东滨州256603

出　　处：《药学研究》2019年第2期112-114,共3页Journal of Pharmaceutical Research

基　　金：滨州医学院科技计划项目(No.BY2013KJ35)

摘　　要：目的比较两种药物联合应用治疗镇静催眠药中毒治疗效果的优劣。方法根据我院急诊科临床用药情况将2016年1月～2018年12月收治的59例镇静催眠药中毒患者分为纳洛酮、氟马西尼联合治疗组(A组);醒脑静、氟马西尼联合治疗组(B组),比较两组患者格拉斯哥昏迷评分(GCS)、苏醒时间、住院时间、不良反应等,分析两种联合用药情况的优劣。结果两组患者治疗后格拉斯哥昏迷评分、苏醒时间、住院时间差异具有统计学意义(P<0.05),B组治疗效果优于A组。结论醒脑静、氟马西尼联合治疗镇静催眠药中毒,能明显缩短住院时间,效果优于纳洛酮和氟马西尼。Objective To compare the efficacy of two drugs in the treatment of sedative hypnotic drug poisoning. Methods The date of 59 patients with sedative hypnotic drug poisoning treated in emergency department of our hospital from January 2016 to December 2018 were selected according to the different treatment regimen and divided into two groups:Naloxone and Flumazenil combined treatment group (group A),Xingnaojing and Flumazenil combined treatment group (group B).GCS (Glasgow Coma Score),recovery time,hospitalization time and adverse reactions were compared. Results The results of GCS (Glasgow Coma Score),recovery time and hospital stay significantly became better than before treatment.The therapeutic effect of B group was better than A group ( P <0.05). Conclusion Xingnaojing combined with Flumazenil in the treatment of sedative hypnotic drug poisoning can significantly shorten the hospital stay and the effect is better than Naloxone and Flumazenil.

关 键 词：氟马西尼 纳洛酮 醒脑静 镇静催眠药中毒 

分 类 号：R971[医药卫生—药品]