超高效液相色谱-串联质谱法快速测定水中双氯酚酸和卡马西平  

Rapid Determination of Diclofenac and Carbamazepine in Water by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

作　　者：曹荥玉 汤庆会 牛璐瑶 刘玉红[1] 余沛芝 赵赛君[1] 刘洪波[2] CAO Xingyu;TANG Qinghui;NIU Luyao;LIU Yuhong;YU Peizhi;ZHAO Saijun;LIU Hongbo(Suzhou Industrial Park Qingyuan&Hongkong China Water Co.,Ltd.,Suzhou 215021,China;School of Environment and Architecture,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]苏州工业园区清源华衍水务有限公司,江苏苏州215021 [2]上海理工大学环境与建筑学院,上海200093

出　　处：《净水技术》2019年第3期5-8,共4页Water Purification Technology

基　　金：上海市科委国际合作项目(18230712300);上海市曙光计划(18SG45);江苏省六大人才高峰计划(2016-JNHB-091)

摘　　要：以固相萃取(SPE)富集被测物,采用超高效液相色谱-串联质谱(UPLC-MS/MS)联用分析技术,建立阳澄湖水体中典型药品和个人护理用品(PPCPs)双氯芬酸、卡马西平的定量分析方法。选用亲水和亲脂平衡(HLB)小柱为固相萃取柱,水样经富集洗脱后通过UPLC-MS/MS检测,一个样品只需5 min即可完成分析。在最优条件下,目标物的线性范围可达0.1～20 ng/L,线性相关系数大于0. 995。双氯芬酸和卡马西平的最低检出限分别为0. 08 ng/L和0. 02 ng/L。目标物的加标回收率在80%～110%。试验建立的方法检出限低、回收率高、检测时间短,适用于阳澄湖水体中典型PPCPs目标物的同时检测。The detection of typical pharmaceuticals and personal care products (PPCPs) diclofenac and carbamazepine in Yangchenghu Lake was studied by solid-phase extraction (SPE) with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).Through enrichment and elution by the use of hydrophilic and lipophilic balance (HLB) column,a sample could be analyzed by UPLC-MS/MS in only 5 minutes.Good linearity (≥0.995) could be obtained under the optimal condition when the target PPCPs were in the range of 0.1~20 ng/L.Detection limits of the method for diclofenac and carbamazepine were 0.08 ng/L and 0.02 ng/L,respectively.The recoveries of the two compounds were between 80% and 110%.With the advantages of low detection limit,high recovery rate and short detection time,this method was suitable for the simultaneous detection of typical PPCPs in Yangchenghu Lake.

关 键 词：药品和个人护理用品 双氯芬酸 卡马西平 超高效液相色谱-串联质谱 

分 类 号：TU991.11[建筑科学—市政工程]