乳腺癌组织转移相关蛋白-3表达与腋窝淋巴结转移的相关性  

Expression of metastasis associated protein-3 in breast cancer tissue and its relationship with axillary lymph node metastasis

作　　者：熊裕民[1] 王治伟[1] 金鑫[1] 洪伟[1] 李福广[1] 姚书鹏 赵子龙[2] 柳俊[2] 高小鹏[3] XIONG Yumin;WANG Zhiwei;JIN Xin;HONG Wei;LI Fuguang;YAO Shupeng;ZHAOZilong;LIU Jun;GAO Xiaopeng(Department of General Surgery,Ankang Central Hospital,Ankang 725000,Shaanxi,China;Department of Pathology,Ankang Central Hospital,Ankang 725000,Shaanxi,China;Second Department of General Surgery,Xi'an Central Hospital,Xi'an 710003,Shaanxi,China)

机构地区：[1]安康市中心医院普通外科,陕西安康725000 [2]安康市中心医院病理科,陕西安康725000 [3]西安市中心医院普外二科,陕西西安710003

出　　处：《检验医学》2019年第3期206-210,共5页Laboratory Medicine

摘　　要：目的探讨乳腺癌患者转移相关蛋白(MTA)-3的表达情况及其与腋窝淋巴结转移的关系。方法收集122例乳腺癌(浸润性导管癌)患者的癌组织和20例乳腺增生症患者的乳腺组织(对照),采用免疫组化法检测组织样本中MTA-3的表达情况,并结合相关临床资料分析MTA-3与临床病理特征、Ki-67和上皮细胞钙黏蛋白(E-cadherin)的关系。按是否合并腋窝淋巴结转移将乳腺癌患者分为转移组(55例)和非转移组(67例)。结果乳腺癌组织中MTA-3的阳性表达率为32.8%,明显低于对照乳腺组织(85.0%)(P=0.000)。MTA-3阳性表达与组织学分级、临床分期、原发肿瘤大小、有无腋窝淋巴结转移及分子分型有关(P<0.05),与年龄、月经状态及体质量指数无关(P>0.05)。转移组组织学分级、临床分期及分子分型与非转移组比较差异均有统计学意义(P<0.05),而年龄、月经状态、体质量指数、原发肿瘤大小2个组之间差异均无统计学意义(P>0.05)。Logistic多因素回归分析显示乳腺癌组织MTA-3阳性表达是乳腺癌患者合并腋窝淋巴结转移的保护性因素[比值比(OR)=0.662,95%可信区间(CI) 0.246～0.891]。MTA-3阳性表达与腋窝淋巴结转移数目、Ki-67阳性表达呈负相关(r=-0.197,P=0.030;r=-0.358,P=0.000),与E-cadherin阳性表达呈正相关(r=0.237,P=0.009)。结论乳腺癌组织中MTA-3表达显著降低,可能与乳腺癌的发生和腋窝淋巴结转移有关。Objective To investigate the expression of metastasis associated protein(MTA)-3 in breast cancer patients and its relationship with axillary lymph node metastasis.Methods The tumor tissues of 122 patients with breast cancer(infiltrating ductal carcinoma)and normal breast tissues(control group)of 20 cyclomastopathy patients were collected.Immunohistochemistry was used for determining the expression of MTA-3.Combined with their clinicopathological data,the relations of MTA-3 with clininopathological characteristics,Ki-67 and epithelial cadherin(E-cadherin)were evaluated.According to the status of axillary lymph node metastasis,the patients with breast cancer were classified into metastasis group(55 cases)and non-metastasis group(67 cases).Results The expression of MTA-3 in breast cancer group(32.8%)was lower than that in control group(85.0%)(P=0.000).MTA-3 expression was related with histological differentiation,clinical stage,primary tumor size,axillary lymph node metastasis and molecular classification(P<0.05),without age,menstruation and body mass index(P>0.05).There was statistical significance in histological differentiation,clinical stage and molecular classification between metastasis and non-metastasis groups(P<0.05).There was no statistical significance in age,menstruation,body mass index or primary tumor size(P>0.05).Multivariate Logistic regression analysis showed that MTA-3 expression was a protective factor of axillary lymph node metastasis for patients with breast cancer[odds ratio(OR)=0.662,95%confidence interval(CI)0.246-0.891].The expression of MTA-3 had negative correlations with the number of axillary lymph node metastasis(r=-0.197,P=0.030)and Ki-67(r=-0.358,P=0.000),while there was a positive correlation with E-cadherin(r=0.237,P=0.009).Conclusions MTA-3 is lowly expressed and is related with axillary lymph node metastasis in breast cancer.

关 键 词：转移相关蛋白-3 乳腺癌 腋窝淋巴结 肿瘤转移 

分 类 号：R446.1[医药卫生—诊断学]