ADH1B和ALDH2基因多态性与相关疾病研究进展  

Research progress of gene polymorphisms of ADH1B and ALDH2 and their related diseases

作　　者：张晓敏 刘静[1] 高世超[1] 杨婷婷[1] 王培昌[1] ZHANGXiaomin;LIU Jing;GAO Shichao;YANG Tingting;WANG Peichang(Department of Clinical Laboratory,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院检验科,北京100053

出　　处：《检验医学》2019年第3期271-275,共5页Laboratory Medicine

基　　金：国家自然科学基金项目(81472007);北京市医院管理局"登峰"人才培养计划(DFL20180803)

摘　　要：乙醇脱氢酶(ADH)和乙醛脱氢酶(ALDH)是人体肝脏内乙醇代谢的关键酶,共同构成ADH氧化体系。ADH1B和ALDH2分别是ADH和ALDH的2个重要亚型。ADH1B和ALDH2基因多态性与多种疾病,如消化系统疾病、神经退行性变及代谢性疾病等相关。文章对ADH1B及ALDH2基因多态性与相关疾病的关系进行综述,以期为疾病的预防和诊断提供新的思路。Alcohol dehydrogenase(ADH)and aldehyde dehydrogenase(ALDH)are key enzymes of alcohol metabolism in human liver,which constitute ethanol dehydrogenase oxidation system.ADH1B and ALDH2 are 2 important subtypes of ADH and ALDH,respectively.ADH1B and ALDH2 gene polymorphisms are associated with a variety of diseases,such as digestive system diseases,neurodegenerative disorders and metabolic diseases.In this review,the gene polymorphisms of ADH1B and ALDH2 and their related diseases are reviewed to provide new ideas for the prevention and diagnosis of diseases.

关 键 词：乙醇脱氢酶1B 乙醛脱氢酶2 基因多态性 疾病 

分 类 号：Q554[生物学—生物化学]