抗微生物药物管理实施前后特殊级抗菌药物使用情况分析  

Utilization of Antibiotics for Special Use Before and After the Implementation of Antimicrobial Stewardship

作　　者：王冠杰 孙清海[1] 赵斌[1] 王振华[1] WANG Guanjie;SUN Qinghai;ZHAO Bin;WANG Zhenhua(Department of Clinical Pharmacy, Weifang Traditional Chinese Hospital, Weifang, Shandong, China 261041)

机构地区：[1]山东省潍坊市中医院临床药学科,山东潍坊261041

出　　处：《中国药业》2019年第7期91-93,共3页China Pharmaceuticals

基　　金：山东省潍坊市科技发展计划项目[2017YX046];山东省潍坊市卫生局科研项目[2014120]

摘　　要：目的提高特殊级抗菌药物的应用合理性。方法对医院2017年1月至12月抗微生物药物管理(AMS)实施前后特殊级抗菌药物应用情况进行回顾性分析,比较特殊级抗菌药物的品规数、使用金额、使用率、微生物使用前送检率、用药频度(DDDs)、使用强度(AUD)及细菌耐药率的变化。结果与AMS实施前相比,实施后特殊级抗菌药物的品规数、使用金额、使用率有较大下降,使用前送检率有所上升,DDDs及AUD下降显著(P <0.05),耐药菌的检出率有下降趋势。结论实施AMS可显著降低特殊级抗菌药物的使用率及使用强度,降低细菌的耐药率,以及提高其使用合理率。Objective To improve the rationality of the utilization of antibiotics for special use.Methods The utilization of antibiotics for special use before and after the implementation of antimicrobial stewardship(AMS) from January to December,2017 were retrospectively analyzed,and the changes of varieties,cost,utilization ratio,inspection rate of microorganism before use of antibiotics,DDDs,AUD and bacterial resistance rate of antibiotics for special use were compared.Results Compared with before implementation of AMS, the varieties,cost and utilization ratio of antibiotics for special use decreased,the inspection rate of microorganism before use of antibiotics increased, the DDDs and AUD decreased significantly(P < 0.05), and the inspection rate of drug-resistant bacteria had a downward trend.Conclusion The implementation of AMS can significantly reduce the utilization ratio and use intensity of antibiotics for special use,reduce the drug resistance rate of bacteria,and improve the rational utilization ratio.

关 键 词：抗微生物药物管理 特殊级抗菌药物 使用率 使用强度 细菌耐药性 合理用药 

分 类 号：R952[医药卫生—药学] R978