多力玛结合人绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的疗效  

Efficacy of turinal combined with human chorionic gonadotropin in the treatment of threatened abortioncaused by luteal insufficiency

作　　者：汪艳 雷侠[2] 黄咏梅 WANG Yan;LEI Xia;HUANG Yongmei(The Third Department of Obstetrics,Xi'an Gaoxin Hospital,Xi'an 710068,Shaanxi,China;Department of Gynecology,Yan’an UniversityAffliatedHos- pital,Yan'an 716000,Shaanxi,China)

机构地区：[1]西安高新医院产三科,陕西西安710068 [2]延安大学附属医院妇科,陕西延安716000

出　　处：《中国性科学》2019年第3期92-95,共4页Chinese Journal of Human Sexuality

基　　金：陕西省科学技术研究发展计划项目(2015HM-01-04)

摘　　要：目的探讨多力玛结合人绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的疗效。方法随机选取2014年5月至2017年5月西安高新医院诊治的黄体功能不全引起先兆流产的106例患者为研究对象。依据治疗方法将这些患者分为多力玛结合人绒毛膜促性腺激素治疗组(结合治疗组,53例)和单独人绒毛膜促性腺激素治疗组(单独治疗组,53例)两组,对两组患者的HCG、E2、P水平、临床疗效、不良反应发生情况进行统计分析。结果两组患者治疗后6周、7周、8周、9周的HCG、E2、P水平均逐渐提升,差异具有统计学意义(P<0.05);治疗后8周结合治疗组患者的P水平显著低于单独治疗组,差异具有统计学意义(P<0.05)。结合治疗组患者治疗的总有效率94.3%(50/53)显著高于单独治疗组73.6%(39/53),差异具有统计学意义(P<0.05),但两组患者的不良反应发生率22.6%(12/53)、18.9%(10/53)之间的差异无统计学意义(P>0.05)。结论多力玛结合人绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的疗效较人绒毛膜促性腺激素治疗显著。Objective To investigate the efficacy of turinal combined with human chorionic gonadotropin ( HCG) in the treatment of threatened abortioncaused byluteal insufficiency. Methods 106 patients with threatened abortioncaused byluteal insufficiency from May 2014 to May 2017 in Xi'an Gaoxin Hospital were randomly selected and divided into combined treatment group (n =53) andsingle treatment group (n =53). The combined treatment group received turinal combined with HCG while the signal treatment group received HCG alone. The HCG, E2, P levels, clinical efficacy and incidences of adverse reactions in the two groups were statistically analyzed. Results The HCG, E2 and P levels in the two groups increased gradually at 6 weeks, 7 weeks, 8 weeks and 9 weeks after treatment, with statisticallysignificant differences(P <0. 05). The P level of combined treatment group was significantly lower than that of single treatment group at 8 weeks after treatment, with statisticallysignificantdif- ferences(P < 0. 05 ). The total effective rate of combined treatment group (94.3%, 50/53) was significantly higher than that of single treatment group (73. 6%, 39/53), with statisticallysignificant difference (P <0. 05), but the difference in incidence of adverse reactions between the two groups was not statisticallysignificant (22. 6%, 12/53 vs 18. 9%, 10/53 )( P > 0. 05 ). Conclusions Turinal combined with HCG is of more significant effect in the treatment of threatened abortioncaused byluteal insufficiency than single HCG treatment.

关 键 词：多力玛结合人绒毛膜促性腺激素 黄体功能不全 先兆流产 

分 类 号：R714[医药卫生—妇产科学]