不同种类他汀药物对慢性硬膜下血肿治疗的临床效果  

Clinical effects of different kinds of statins in the treatment of chronic subdural hematoma

作　　者：徐涛[1] XU Tao(Trauma Center, the First Hospital of Nanchang City, Nanchang 330008, China)

机构地区：[1]南昌市第一医院创伤中心,江西南昌330008

出　　处：《中国现代医生》2019年第5期86-88,共3页China Modern Doctor

摘　　要：目的探讨不同种类他汀药物对慢性硬膜下血肿治疗的临床效果。方法选择2015年12月～2017年12月本院收治的慢性硬膜下血肿患者120例,按照使用他汀类药物不同分为三组,均为40例。所有患者均行对症支持处理,A组使用辛伐他汀(40 mg/d,晚间顿服),B组使用匹伐他汀(口服,每次1 mg,每天1次),C组使用阿托伐他汀(40 mg/d),比较各组患者的临床治疗效果,比较各组慢性硬膜下血肿治疗效果及各组硬膜下血肿吸收时间。结果 C组总有效率显著高于A组和B组(P<0.05),C组硬膜下血肿吸收时间为(25.1±0.3)d;B组硬膜下血肿吸收时间为(38.2±1.6)d,A组硬膜下血肿吸收时间为(41.2±1.8)d;C组硬膜下血肿吸收时间优于A组和B组(t=19.814,P=0.000<0.05)。结论针对慢性硬膜下血肿使用40 mg/d的阿托伐他汀治疗,能更好地提高患者临床治疗效果,促进神经功能恢复,值得推广。Objective To explore the clinical effects of different kinds of statins in the treatment of chronic subdural hematoma. Methods 120 patients with chronic subdural hematoma admitted to our hospital from December 2015 to December 2017 were selected and divided into 3 groups according to the kinds of statins used, 40 cases in each group. All patients were given symptomatic support. Group A was given simvastatin(40 mg/d, once in the evening), group B was given pitavastatin (orally, 1 mg per time, qd), and group C was given atorvastatin (40 mg/day). The clinical effects, the therapeutic effects of chronic subdural hematoma and the absorption time of subdural hematoma in each group were compared. Results The total effective rate of group C was significantly higher than those of group A and group B(P< 0.05). The absorption time of subdural hematoma in group C was(25.1±0.3)d;in group B was(38.2±1.6)d;and in group A was(41.2±1.8) d;the absorption time of subdural hematoma in group C was shorter than those in group A and group B(t=19.814, P=0.000<0.05). Conclusion For patients with chronic subdural hematoma, the use of 40 mg/day of atorvastatin can improve the clinical effect and promote the recovery of neurological function in patients, so it is worth promoting.

关 键 词：不同剂量 阿托伐他汀 辛伐他汀 匹伐他汀 慢性硬膜下血肿 

分 类 号：R651.15[医药卫生—外科学]