普瑞巴林联合依托考昔治疗乳腺癌根治术后疼痛的临床疗效观察  

Clinical observation of pregabalin combined with etocoxib in the treatment of pain after radical mastectomy for breast cancer

作　　者：林涛[1] 江平[1] 代月娥[1] 李祥奎[1] 宋俊梅[2] LIN Tao;JIANG Ping;DAI Yue-e;LI Xiang-kui;SONG Jun-mei(Department of Anesthesiology,Sichuan Provincial People’s Hospital,Chengdu 610072,Sichuan,China;Cardiac Function Division,Sichuan Provincial People’s Hospital,Chengdu 610072,Sichuan,China)

机构地区：[1]四川省人民医院麻醉科,四川成都610072 [2]四川省人民医院心功能科,四川成都610072

出　　处：《川北医学院学报》2019年第1期45-47,58,共4页Journal of North Sichuan Medical College

基　　金：四川省卫计委科研课题(16PJ460)

摘　　要：目的:观察普瑞巴林联合依托考昔治疗乳腺癌根治术后疼痛的临床效果。方法:选取行乳腺癌根治术的60例患者为研究对象,随机分为观察组和对照组,每组各30例。对照组患者给予依托考昔,观察组患者给予普瑞巴林和依托考昔,两组患者均治疗两周。观察治疗后1 d、2 d、3 d、7 d、10 d、14 d视觉模拟评分(VAS),根据治疗后14 d的VAS结果评价治疗后镇痛满意度,并记录两组患者不良反应发生情况。在上述时间点采集IL-1β、IL-6、TNF-α含量。结果:治疗后,观察组患者治疗后3 d、7 d、10 d、14 d的VAS评分(4.51±1.32、3.22±1.31、2.08±1.18、1.13±1.09)明显低于对照组患者(4.84±1.39、3.96±1.29、2.71±1.24、1.49±1.01)(P<0.05);治疗后,观察组镇痛满意度为83.3%,明显高于对照组的60.0%(P<0.05)。治疗后,观察组的恶心、呕吐、头晕、皮肤瘙痒的发生率低于对照组(P<0.05)。在治疗后不同时间点,观察组患者血清中IL-1β、IL-6、TNF-α含量均低于对照组(P<0.05)。结论:普瑞巴林联合依托考昔治疗具有良好的镇痛效果,可用于乳腺癌根治治疗后疼痛患者的镇痛治疗,且不良反应发生少。Objective:To observe the clinical efficacy of pregabalin combined with etocoxib in the treatment of pain after radical mastectomy for breast cancer.Methods:60 cases patients with radical mastectomy were selected as subjects,and the patients were divided into the observation group and the control group,each group had 30 cases.Patients in the control group were given etocoxib,while patients in the observation group were given pregabalin and etocoxib.Both groups were treated for two weeks.Visual analogue scale(VAS) was observed 1,2,3,7,10 and 14 days after treatment.The satisfaction of analgesia was evaluated according to VAS scores 14 days after treatment.The adverse reactions of the two groups were recorded.The contents of IL-1β,IL-6 and TNF-α were collected at the above time points.Results:After treatment,the VAS scores of the patients in the observation group(4.51±1.32,3.22±1.31,2.08±1.18,1.13±1.09) were significantly lower than those in the control group(4.84±1.39,3.96±1.29,2.71±1.24,1.49±1.01) 3,7,10 and 14 days after treatment(P<0.05).After treatment,the satisfaction rate of analgesia in the observation group was 83.3%,which was significantly higher than that in the control group(60.0%,P<0.05).After treatment,the incidence of nausea,vomiting,dizziness and pruritus in the observation group was lower than that in the control group(P<0.05).At different time points after treatment,the serum levels of IL-1β,IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05).Conclusion:Pregabalin combined with etocoxib has good analgesic effect,and can be used for pain relief in patients with breast cancer after radical treatment,and it has fewer adverse reactions.

关 键 词：普瑞巴林 依托考昔 乳腺癌 术后疼痛 

分 类 号：R614[医药卫生—麻醉学]