预防性静脉注射长托宁对急性阑尾炎患者术中寒战的影响  

Effect of prophylactic intravenous Changtuoning on intraoperative chills in patients with acute appendicitis

作　　者：邱勇[1] 罗志勇 付云娟 QIU Yong;LUO Zhi-yong;FU Yun-juan(Department of Anesthesiology,the First People′s Hospital of Fuzhou,Jiangxi Province,Fuzhou 344000,China)

机构地区：[1]江西省抚州市第一人民医院麻醉科,江西抚州344000

出　　处：《中国当代医药》2019年第8期141-143,共3页China Modern Medicine

基　　金：江西省抚州市指导性科技计划项目(抚科计字[2017]25号;第25项)

摘　　要：目的探讨预防性静脉注射长托宁对急性阑尾炎患者术中寒战的影响。方法选取2015年10月～2017年2月在我院行急性阑尾炎手术的62例患者作为研究对象,按照入院时间顺序将其随机分为对照组和观察组,每组各31例。对照组患者静脉注射哌替啶进行麻醉,观察组患者静脉注射盐酸戊乙奎醚进行麻醉。观察并比较两组患者用药前后的血氧饱和度(SpO_2)、平均动脉压(MAP)、心率(HR)生命体征变化情况,寒战总发生率及用药后不良反应发生情况。结果两组患者注射前的SpO_2、HR、MAP比较,差异无统计学意义(P>0.05);对照组患者注射药物后5、10、15、20 min的SpO_2均明显低于注射前,差异有统计学意义(P<0.05);观察组患者注射药物后5、10、15、20 min的SpO_2均明显高于对照组,差异有统计学意义(P<0.05);两组患者注射药物后5、10、15、20 min的HR、MAP比较,差异无统计学意义(P>0.05)。观察组患者的寒战总发生率为6.45%,明显低于对照组的22.58%,差异有统计学意义(P<0.05)。观察组患者的不良反应总发生率显著低于对照组,差异有统计学意义(P<0.05)。结论静脉注射盐酸戊乙奎醚可以预防急性阑尾炎患者术中寒战的发生,且对患者体温、HR、血压无影响,值得临床推广。Objective To investigate the effect of prophylactic intravenous Changtuoning on intraoperative chills in patients with acute appendicitis. Methods A total of 62 patients with acute appendicitis who underwent operation in our hospital from October 2015 to February 2017 were selected as research subjects. According to the time of admission,they were randomly divided into control group and observation group,31 cases in each group. Patients in the control group were anesthetized with intravenous Pethidine,and patients in the observation group were anesthetized with intravenous Penehyclidine Hydrochloride. The changes of vital signs like blood oxygen saturation (SpO2),mean arterial pressure (MAP),and heart rate (HR) before and after medication,the total incidence rate of chills and adverse reactions after medication were observed and compared between the two groups. Results There were no significant differences in SpO2,HR and MAP between the two groups before injection (P>0.05). The SpO2 at 5,10,15 and 20 min after injection of the drug in the control group was significantly lower than that before injection,and the differences were statistically significant (P<0.05). The SpO2 at 5,10,15 and 20 min after injection of the drug in the observation group was significantly higher than that in the control group,and the differences were statistically significant (P<0.05). There were no significant differences in HR and MAP between the two groups at 5,10,15 and 20 min after injection (P>0.05). The total incidence rate of chills in the observation group was 6.45%,which was significantly lower than that in the control group (22.58%),and the difference was statistically significant (P<0.05). The total incidence rate of adverse reactions in the observation group was significantly lower than that in the control group,and the difference was statistically significant (P<0.05). Conclusion The intravenous injection of Penehyclidine Hydrochloride can prevent the occurrence of chills in patients with acute appendicitis,and has no effect

关 键 词：急性阑尾炎 术中 盐酸戊乙奎醚 哌替啶 寒战 

分 类 号：R614[医药卫生—麻醉学]