颈淋巴结核对罗库溴铵肌松效应的影响  

Influence of cervical lymphatic tuberculosis on muscle relaxation effect of Rocuronium Bromide

作　　者：韩亚坤[1] 刘民强[1] 余德慧 胡菽君 HAN Ya-kun;LIU Min-qiang;YU De-hui;HU Shu-jun(Department of Anesthesiology,the Third People's Hospital of Shenzhen, Guangdong Province,Shenzhen 518116,China)

机构地区：[1]深圳市第三人民医院麻醉科,广东深圳518116

出　　处：《中国当代医药》2019年第8期144-146,共3页China Modern Medicine

摘　　要：目的探讨颈淋巴结核对罗库溴铵按体表面积给药肌松效应的影响。方法选取2017年5～10月于我院行全麻下颈部肿物切除手术40例患者作为研究对象,按照疾病类型将其分为结核病组(T组)与非结核病组(NT组),每组各20例。全麻诱导时按体表面积计算给予2倍ED95罗库溴铵,待拇内收肌四个成串刺激(TOF)第4个肌颤搐与第1个肌颤搐的比值(T4/T1,TOFr)降至0%时行气管插管。记录两组患者的气管插管条件、起效时间、临床作用时间、恢复指数及药理作用时间。结果两组患者的气管插管条件比较,差异无统计学意义(P>0.05)。两组患者的起效时间、恢复指数及药理作用时间比较,差异无统计学意义(P>0.05);T组患者的罗库溴铵临床作用时间为(24.0±4.6)min,明显短于NT组的(28.0±3.6)min,差异有统计学意义(P<0.05)。结论颈淋巴结核患者罗库溴铵按体表面积给药的临床作用时间较非结核患者短,围术期追加用药的间隔时间宜适当缩短。Objective To investigate the influence of cervical lymphatic tuberculosis on the muscle relaxation effect of Rocuronium Bromide when administrated by body surface area. Methods Forty patients who underwent general anesthesia for neck mass resection in our hospital from May to October 2017 were selected as study objects and they were divided into tuberculosis group (group T) and non-tuberculosis group (group NT) according to the disease type, 20 cases in each group. In the induction of general anesthesia, according to the body surface area, 2 times of ED95 Rocuronium Bromide was administered. The tracheal intubation was performed when the ratio of the fourth muscle twitch to the first muscle twitch (T4/T1, TOFr) of the train-of-four (TOF) stimulation of the abductor pollicis muscle was reduced to 0%. The tracheal intubation conditions, onset time, clinical duration, recovery index and pharmacological time were recorded between the two groups. Results There were no significant differences in tracheal intubation conditions between the two groups (P>0.05). There were no significant differences in onset time, recovery index and pharmacological time between the two groups (P>0.05). The clinical duration of Rocuronium Bromide in group T was (24.0±4.6) min, which was significantly shorter than that in group NT of (28.0±3.6) min, and the difference was statistically significant (P<0.05). Conclusion The clinical action duration of administration of Rocuronium Bromide in patients with cervical lymphatic tuberculosis by body surface area is shorter than that of non-tuberculosis patients, and the interval between additional medications during perioperative period should be appropriately shortened.

关 键 词：颈淋巴结核 罗库溴铵 体表面积 药效学 

分 类 号：R969.1[医药卫生—药理学]