基于有机薄膜晶体管与有机电化学晶体管的生物传感器研究进展  

Advances in Biosensors Based on Organic Thin Film Transistors and Organic Electrochemical Transistors

作　　者：冯晓倩 顾文[1] 张霞[1] 蒋浩 FENG Xiaoqian;GU Wen;ZHANG Xia;JIANG Hao(School of Materials Engineering,Shanghai University of Engineering Science,Shanghai 201620)

机构地区：[1]上海工程技术大学材料工程学院,上海201620

出　　处：《材料导报》2019年第7期1243-1250,共8页Materials Reports

基　　金：国家自然科学基金(11704242;11705115);上海市高校青年教师培养资助计划(ZZGCD16020)~~

摘　　要：生物传感器是一门由生物、化学、物理、医学、电子技术等多种学科互相渗透成长起来的高新技术,在国民经济的各个领域如食品、制药、化工、临床检验、生物医学、环境监测等方面有着重要应用。生物传感器选择性好、灵敏度高、分析速度快、成本低,可在复杂的体系中进行在线连续监测,特别是具有高度自动化、微型化与集成化的特点,其在近几十年获得了蓬勃而迅速的发展。在生物传感器领域,有机电子器件具有广阔的应用前景,特别是在低成本、一次性、便携、柔性弯曲等方面,有机电子器件显示出无可比拟的优势。在有机电子学领域,引起广泛关注和研究的包括有机薄膜晶体管(Organic thin film transistors,OTFTs)生物传感器和有机电化学晶体管(Organic electrochemical transistors,OECTs)生物传感器两种技术。其中,OTFTs生物传感器采用全固态薄膜制备,由于其制备工艺简单且可与传统半导体加工工艺相兼容,因而方便集成。此外,OTFTs生物传感器的检测单元多样化,不仅限于有机半导体层,其栅极和源漏电极都可用作生物检测。目前,在该生物传感器中已成功应用的高性能有源层材料有并五苯(Pentacene)、聚(3-己基噻吩)(P3HT)和聚苯胺(PANI)等。研究工作包括DNA表面固定方法改进、传感器结构设计与灵敏度优化、新型扩展栅极结构等。由于大多数检测在非溶液体系中进行,其检测的便捷性和灵敏度受到了一定限制。为了解决溶液体系下的检测问题,OECTs生物传感器被提出。该传感器不仅具有工作电压低(一般小于1 V)、电化学活性强以及可在溶液环境下工作等优点,而且其沟道与栅极的距离可按需调节。OECTs生物传感器的出现为发展高灵敏、高特异性的生物分析检验方法注入了活力。目前,OECTs生物传感器已成功应用于脱氧核糖核酸(Deoxyribonucleic acid,DNA)、抗原和细菌等�Biosensor is a novel high technology that derived from multidiscipline including biology,chemistry,physics,medicine,and electronic technology.It has vast application in diverse field of the national economy such as food,pharmaceuticals,chemical industry,clinical testing,biomedicine,and environmental monitoring.Featured by high selectivity,high sensitivity,fast analysis speed,low cost,and continuous on-line monitoring in complex systems,especially high degree of automation,miniaturization,and integration,biosensors have developed vigorously and swiftly in recent decades.In the field of biosensors,organic electronic devices exhibit broad application prospects and unparalleled advantages,especially in low-cost,disposable,portable,flexible bending,etc.In the field of organic electronics,there are two kind of biosensors,namely organic thin film transistors(OTFTs)biosensors and organic electrochemical transistors(OECTs)biosensors,that aroused widespread concerns and interests.OTFTs biosensors are made of all-solid-state film,which is convenient to integrate because of its process simplicity and compatibility with traditional semiconductor processing technology.In addition,OTFTs biosensors possess diversified detection units,which is not limited to the organic semiconductor layer and include gate and source leakage electrodes.At present,high-performance active layer materials like pentacene,poly(3-hexylthiophene)(P3HT),and polyaniline(PANI)have been successfully used in the biosensor.Research work mainly lies in improvements in DNA surface immobilization methods,sensor structure design and sensitivity optimization,and new extended gate structures.There is a certain limitation for the detection in convenience and sensitivity,due to the fact that most of the tests are implemented in a non-aqueous system.For the sake of achieving the detection in aqueous system,OECTs biosensor is proposed.OECTs sensors are not only has the superior in low operating voltage(generally less than 1 V),strong electrochemical activity and capabi

关 键 词：生物传感器 有机薄膜晶体管 有机电化学晶体管 灵敏度 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]