强化胰岛素治疗的2型糖尿病患者夜间低血糖危险因素调查研究  

Investigation on risk factors of nocturnal hypoglycemia in type 2 diabetes patients treated with intensive insulin therapy

作　　者：周莹霞[1] 张翼飞[1] 王姝洁[1] 王卫庆[1] ZHOU Yingxia;ZHANG Yifei;WANG Shujie;WANG Weiqing(Department of Endocrinology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科,上海200025

出　　处：《内科理论与实践》2018年第6期375-378,共4页Journal of Internal Medicine Concepts & Practice

摘　　要：目的 :探讨强化胰岛素治疗的2型糖尿病患者夜间低血糖的危险因素。方法 :对501例强化胰岛素治疗2型糖尿病患者的临床资料进行回顾性分析,收集发生至少1次以上夜间低血糖患者临床资料,对收集的变量进行单因素分析和多因素分析。结果:高体质量指数(body mass index,BMI)、高三酰甘油和高空腹血糖是强化胰岛素治疗的2型糖尿病患者发生夜间低血糖的保护因素(均P<0.05),而平均血糖波动幅度(mean amplitude of plasma glucose excursions,MAGE)、血糖标准差(standard deviation of blood glucose,SDBG)增高则是危险因素(P<0.05)。结论:应加强夜间低血糖危险因素的防控,规范血糖监测,加强对患者的观察处理,避免夜间低血糖的发生。Objective To study the risk factors of nocturnal hypoglycemia in type 2 diabetes patients treated with intensive insulin therapy. Methods A total of 501 type 2 diabetes patients treated with intensive insulin therapy were retrospectively analyzed. The related risk factors of nocturnal hypoglycemia were analyzed by univariate and multivariate Logistic multi-regression analysis. Results Higher body mass index(BMI) and triglyceride level were the protective factors of night hypoglycemia in type 2 diabetes treated with intensive insulin therapy(P<0.05), and the lower fasting blood glucose and higher mean amplitude of plasma glucose excursions(MAGE) and standard deviation of blood glucose(SDBG) were the risk factors of night hypoglycemia(P <0.05). Conclusions To avoid the occurrence of nocturnal hypoglycemia, the prevention and control of risk factors should be strengthened, the monitoring of blood glucose at night be enhanced, and the observation of patient be standardized.

关 键 词：2型糖尿病 夜间低血糖 强化胰岛素治疗 危险因素 

分 类 号：R587.1[医药卫生—内分泌]