药代动力学过程中的中西药配伍禁忌  

The incompatibility of Chinese and Western medicine based on pharmacokinetics

作　　者：杨洋 曾卉 李方园 高宇琪 周好好 黄翠萍[3] YANG Yang;ZENG Hui;LI Fangyuan;GAO Yu-qi;ZHOU Hao-hao;HUANG Cui-ping(College of pharmacy,Hubei University of Science and Technology,Xianning 437100,Hubei;Shenzhen Bao'an Traditional Chinese Medicine Hospital Group,Shenzhen 518000;Clinical medical college,Hubei University of Science and Technology,Xianning 437100,Hubei)

机构地区：[1]湖北科技学院药学院,湖北咸宁437100 [2]深圳市宝安中医院(集团),深圳518000 [3]湖北科技学院临床医学院,湖北咸宁437100

出　　处：《中药与临床》2018年第5期45-49,共5页Pharmacy and Clinics of Chinese Materia Medica

基　　金：湖北省教育厅重点项目(编号:D20132806)

摘　　要：近年来,中西药联合用于防治疾病的现象日趋增多,但疗效降低、毒副作用增强等现象多有发生,存在很多配伍禁忌。本文根据药物体内药代动力学过程,研究存在配伍禁忌的中西药药物组合在体内的吸收、分布、代谢、排泄过程的变化,揭示其增毒减效的影响因素、可能途径及内在机制,以期为中西药科学配伍及临床合理用药提供指导与支持,为中西药配伍禁忌研究提供借鉴和示范。In recent years, the combination of Chinese and Western medicine for disease prevention and treatment is increasing. However, the efficacy reduction and side effects is frequently reported with many incompatibilities. Based on the pharmacokinetic of drugs in vivo, we studied the absorption, distribution, metabolism and excretion process of the combination of Chinese and Western medicine with incompatibility, and revealed the influencing factors, possible pathways and internal mechanisms of its increasing toxicity and reducing efficacy. It is expected to provide guidance and support for the compatibility of Chinese and Western medicine and clinical rational use of drugs, and provide reference and demonstration for Chinese and Western medicine incompatibility study.

关 键 词：中西药 药代动力学 配伍禁忌 

分 类 号：R285[医药卫生—中药学]