平阳霉素联合地塞米松注射治疗咽喉部血管瘤的临床分析  

Clinical analysis of pingyangmycin combined with dexamethasone injection in the treatment of pharyngeal and laryngeal hemangioma

作　　者：于书剑 Yu Shujian(Department of Otolaryngology, Bethune First Hospital of Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学白求恩第一医院耳鼻咽喉头颈外科,长春130021

出　　处：《血管与腔内血管外科杂志》2018年第5期433-438,共6页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨平阳霉素联合地塞米松局部注射治疗咽喉部血管瘤的临床效果。方法选取2012年10月至2017年10月期间吉林大学白求恩第一医院收治的52例咽喉部血管瘤患者作为研究对象,采用随机数字表法将其分为观察组和参照组,每组各26例。参照组在电子喉镜下采用平阳霉素进行局部注射治疗,观察组在电子喉镜下采用平阳霉素联合地塞米松进行局部注射治疗。分析统计2组患者咽喉部血管瘤的治疗效果,并观察治疗治疗的不良反应情况。结果观察组治疗的有效率为96.15%,高于参照组的76.92%,差异有统计学意义(P<0.05)。治疗期间2组肝肾功能以及胸片监测均没有明显异常,观察组和参照组患者的不良反应发生率分别为11.54%和38.46%,观察组不良反应低于参照组,比较差异有统计学意义(P<0.05)。结论咽喉部血管瘤采用平阳霉素联合地塞米松进行局部注射治疗,临床效果更显著,不良反应少,安全性较高,值得临床进行推广应用。Objective To investigate the clinical effect of pingyangmycin combined with dexamethasone injection in the treatment of pharyngeal and laryngeal hemangioma. Methods From October 2012 to October 2017, 52 patients with pharyngeal and laryngeal hemangioma were selected as subjects of study. They were divided into observation group and reference group by random digital table method, with 26 cases in each group.The control group was treated by local injection of pingyangmycin under electronic laryngoscope. And the observation group was treated by local injection of pingyangmycin and dexamethasone under electronic laryngoscope. The therapeutic effect of pharynx and throat hemangioma between the two groups of patients was analyzed, and the adverse reactions were observed. Results The effective rate of treatment in the observation group was 96.15%, which was higher than that in the control group(76.92%). The difference was statistically significant(P<0.05). During the treatment period, there was no obvious abnormality in liver and kidney function and chest X-ray monitoring in the two groups. The incidence of adverse reactions in the observation group and the reference group was 11.54% and 38.46%, respectively. The adverse reactions in the observation group were lower than those in the control group. The difference was statistically significant(P<0.05). Conclusion Local injection of pingyangmycin combined with dexamethasone in the treatment of pharyngeal hemangioma is more effective, can also reduce adverse reactions, and has high safety, so it is worth popularizing in clinic.

关 键 词：咽喉血管瘤 平阳霉素 地塞米松 临床效果 不良反应 

分 类 号：R543[医药卫生—心血管疾病]