赝复体式放射性粒子布源器治疗11例腭部腺源性恶性肿瘤的疗效观察  

Clinical evaluation of prosthesis-like applicators with radioactive seeds for treatment of eleven palatal glandular malignancies

作　　者：孟庆飞[1] 孟箭[1] MENG Qing-fei;MENG Jian(Department of Stomatology,Xuzhou Central Hospital. Xuzhou 221009,Jiangsu Province,China)

机构地区：[1]徐州市中心医院口腔科,江苏徐州221009

出　　处：《上海口腔医学》2019年第1期81-84,共4页Shanghai Journal of Stomatology

基　　金：徐州市医学青年后备人才(徐卫科教[2015]7号);江苏省青年医学人才(QNRC2016391);徐州市医学创新(技术攻关)团队(XWCX201604)

摘　　要：目的 :评价赝复体式放射性粒子布源器用于腭部腺源性恶性肿瘤患者的术后放射治疗效果。方法 :11例腭部恶性肿瘤患者,经常规手术切除治疗后2周,根据上颌骨缺损的赝复体设计原则,分别制作铸造支架式赝复体。按照放射性粒子植入治疗计划系统的靶区照射剂量设计要求,在近瘤腔的赝复体基托树脂组织面均匀埋植数枚125I放射性粒子。术后随访观察患者的治疗效果及不良反应。采用SPSS 21.0软件包对数据进行统计学分析。结果:11例患者均能坚持配戴赝复体式放射性粒子布源器,无粒子脱落或移位。随访6～24个月,未见肿瘤复发或远处转移。经赝复体修复后,患者语音清晰度、咀嚼效率、生活质量等均显著改善,自我评估全优。结论:采用赝复体式放射性粒子布源器对腭部腺源性恶性肿瘤患者进行术后近距离靶向照射治疗,可以取得较好的临床疗效,改善患者的生活质量,值得推广应用。PRUPOSE: To evaluate the clinical efficacy of prosthesis-like applicators with radioactive seeds in treatment of palatal glandular malignancy. METHODS: Eleven patients with palatal glandular malignant tumors were treated with surgical resection and postoperative125 I radioactive seed brachytherapy. After resection of the palatal tumors, a prosthesis denture was fabricated for each patient. According to the design of treatment plan system, several125 I radioactive seeds were embedded in the tissue surface of the prosthesis at the same time. All the patients were followed-up for 6 to 24 months and the results were evaluated. SPSS 21.0 software package was used for statistical analysis. RESULTS: Eleven patients could wear prosthesis-like applicators all the time and neither tumor recurrence nor metastasis were found around the target area during the follow-up period. Furthermore, significant improvement was shown in terms of speech,mastication and facial appearance for all patients after prosthesis-like applicator restorations. CONCLUSIONS: For patients with palatal glandular malignant tumors, prosthesis-like applicators with125 I radioactive seed brachytherapy may be effective for preventing recurrence and metastasis of the malignancies and improving the patients’ quality of life.

关 键 词：放射性粒子 近距离照射治疗 腭部恶性肿瘤 布源器 

分 类 号：R739.8[医药卫生—肿瘤]