含Ⅰ型血小板反应蛋白的解聚素样金属蛋白酶9基因rs6795735多态性与血糖表型的相关性及性别差异的研究  

Association analysis of rs6795735 polymorphism in ADAMTS9 gene with glycemic phenotypes and its gender-specific effect

作　　者：宋绮莹 孟祥睿 宋洁云[2] 刘芳宏[2] 马军[2] 王海俊[1] 王燕[1] SONG Qiying;MENG Xiangrui;SONG Jieyun(Department of Maternal and Child Health, School of Public Health, Peking University, Beijifig 100191, China)

机构地区：[1]北京大学公共卫生学院妇幼卫生学系,100191 [2]北京大学儿童青少年卫生研究所

出　　处：《中国糖尿病杂志》2019年第2期81-85,共5页Chinese Journal of Diabetes

基　　金：北京市自然科学基金(7162106)

摘　　要：目的研究含Ⅰ型血小板反应蛋白的解聚素样金属蛋白酶9(ADAMTS9)基因rs6795735多态性与血糖表型的相关性,并分析是否存在性别差异。方法选取北京市2030名7～18岁中小学生,分为肥胖组(n=705)和非肥胖组(n=1325),采用基质支持的激光释放/电离飞行时间质谱分析法检测rs6795735多态性。在显性模型下,采用Logistic回归及多元线性回归分析rs6795735与IFG及血糖表型的相关性。结果rs6795735多态性与IFG相关[OR(95%CI)1. 38(1. 11～1. 71),P=0. 004],与FPG无相关性。按性别分层分析显示,rs6795735与IFG、FPG仅在女性中存在相关性[OR(95%CI)1. 61(1. 14～2. 28),P=0. 007;β(SE)=0. 056(0. 028),P=0. 048],在男性中未发现相关性。结论 ADAMTS9基因rs6795735多态性与IFG、FPG相关,且存在性别差异。在女性中,rs6795735 C等位基因携带者与非携带者比较,FPG水平升高,发生IFG的风险增加。Objective To explore the association between rs6795735 in disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9(ADAMTS9)gene and glycemic phenotypes and its genderspecific effect.Methods This study was conducted in 2030 students aged 7~18 years in Beijing.They were divided into obesity group and non-obesity group.Genotyping of rs6795735 was performed with matrix assisted laser desorption ionization time of flight mass spectrometry(MALDI-TOF MS).Logistic and linear regressions were performed to assess the associations between rs6795735 and glycemic phe no types.Results Rs6795735 was significantly associated with impaired fasting glucose(IFG)[OR(95%CI)1.38(1.11~1.71),P=0.004],while not associated with fasting plasma glucose(FPG).Stratified analysis according to gender showed that rs6795735 was only significantly associated with IFG and FPG in girls[OR(95%C7)1.61(1.14~2.28),P=0.007 and0(SE)=0.056(0.028),P=0.048].No similar association was found in boys.Conclusion Rs6795735 in ADAMTS9 gene was associated with IFG and FPG,and had a gender specific effect.In girls,FPG and IFG risk were higher in s6795735 C allele carriers than in non-C allele carriers.

关 键 词：含Ⅰ型血小板反应蛋白的解聚素样金属蛋白酶9 基因多态性 血糖 肥胖症 儿童 

分 类 号：R587.1[医药卫生—内分泌]